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(4-formylphenyl)-3-(4-methoxyphenyl)urea is a chemical compound with the molecular formula C15H13NO3. It is a white crystalline solid that belongs to the class of urea derivatives, specifically an aryl-aryl urea. (4-formylphenyl)-3-(4-methoxyphenyl)urea is characterized by the presence of a formyl group (-CHO) attached to a phenyl ring and a methoxy group (-OCH3) on another phenyl ring, both of which are connected through a urea linkage. It is synthesized through the reaction of 4-formylbenzoic acid with 4-methoxyphenyl isocyanate. (4-formylphenyl)-3-(4-methoxyphenyl)urea has potential applications in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals due to its unique structural features and reactivity.

26579-29-3

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26579-29-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 26579-29-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,5,7 and 9 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 26579-29:
(7*2)+(6*6)+(5*5)+(4*7)+(3*9)+(2*2)+(1*9)=143
143 % 10 = 3
So 26579-29-3 is a valid CAS Registry Number.

26579-29-3Upstream product

26579-29-3Downstream Products

26579-29-3Relevant academic research and scientific papers

Design and synthesis of novel benzoxazole analogs as Aurora B kinase inhibitors

An, Ying,Lee, Eun,Yu, Yeongji,Yun, Jieun,Lee, Myeong Youl,Kang, Jong Soon,Kim, Woo-Young,Jeon, Raok

, p. 3067 - 3072 (2016/06/13)

A novel series of benzoxazole analogs was designed and synthesized, and their inhibitory activities against Aurora kinases were evaluated. Some of the tested compounds exhibited a promising activity with respect to the inhibition of Aurora B kinase. A structure-activity relationship study indicated that linker length, regiochemistry, and halogen substitution play important roles in kinase inhibitory potency. The binding modes between representative compounds and Aurora kinases were interpreted through a molecular docking study to explain the inhibitory activity and selectivity for Aurora A and B kinases. Compounds 13l and 13q also show an antiproliferative effect on the human tumor cell lines in a dose-dependent manner. The most potent 13q demonstrated good efficacy in the prostate cancer PC-3 tumor xenograft model.

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