26580-32-5

Upstream product

• 868-85-9 Dimethyl phosphite 
• 1192-37-6 methylenecyclohexane 
• 2550-36-9 Cyclohexylmethyl bromide 
• 813-77-4 Dimethyl chlorophosphate 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 26580-04-1 (Cyclohexyl-diazo-methyl)-phosphonic acid dimethyl ester 
• 1490-12-6 Cyclohexanecarbonyl-phosphonic acid dimethyl ester 
• 26580-31-4 Dimethylcyclohexylidenmethylphosphonat 

Downstream Products

• 16016-55-0 Cyclohexylmethylphosphonsaeure 

Relevant academic research and scientific papers

Probing the reactivity of H-phosphonate derivatives for the hydrophosphonylation of various alkenes and alkynes under free-radical conditions

Hydrophosphonylation is an efficient process to create carbon-phosphorus bonds from unsaturated C-C bonds and to give rise to alkylphosphonate or vinylphosphonate derivatives. In this work, we report on the reactivity of H-phosphonate derivatives for the hydrophosphonylation of various alkenes and alkynes under photoinduced free-radical conditions. The reaction was carried out on activated, unactivated and/or disubstituted alkenes or alkynes with 2,2-dimethoxy-2-phenylacetophenone as a photoinitiator under UV irradiation.

Inhibitors of protein isoprenyl transferases

Compounds having the formula or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2—, and (i) heterocyclic-L2—; R2 is selected from(a) (b) —C(O)NH—CH(R14)—C(O)OR15, (d) —C(O)NH—CH(R14)—C(O)NHSO2R16,(e) —C(O)NH—CH(R14)-tetrazolyl, (f) —C(O)NH-heterocyclic, and(g) —C(O)NH—CH(R14)—C(O)NR17R18; R3 is substituted or unsubstituted heterocyclic or aryl, substituted or unsubstituted cycloalkyl or cycloalkenyl, ?and —P(W)RR3RR3′; R4 is hydrogen, lower alkyl, haloalkyl, halogen, aryl, arylakyl, heterocyclic, or (heterocyclic)alkyl; L1 is absent or is selected from (a) —L4—N(R5)—L5—, (b) —L4—O—L5—, (c) —L4—S(O)n—L5—(d) —L4—L6—C(W)—N(R5)—L5—, (e) —L4—L6—S(O)m—N(R5)—L5—, (f) —L4—N(R5)—C(W)—L7—L5—, (g) —L4—N(R5)—S(O)p—L7—L5—, (h) optionally substituted alkylene, (i) optionally substituted alkenylene, (j) optionally substituted alkynylene (k) a covalent bond, (l) and (m) are inhibitors of protein isoprenyl transferases. Also disclosed are protein isoprenyl transferase inhibiting compositions and a method of inhibiting protein isoprenyl transferases.