26583-60-8

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-methylphenoxy)ethanamine is used as a key intermediate in the synthesis of pharmaceutical drugs for its potential pharmacological properties. It is particularly valuable in the development of new medications due to its unique chemical structure and the possibility of its interaction with biological targets.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, 2-(2-methylphenoxy)ethanamine serves as a building block for the creation of various organic compounds. Its reactivity and functional groups make it a versatile component in the synthesis of a wide range of chemical products.
As the specific uses and applications of 2-(2-methylphenoxy)ethanamine are still under research and exploration, its full potential in different industries may not be fully realized yet. However, its presence in the pharmaceutical chemistry field highlights its importance in the development of innovative treatments and therapeutic agents.

InChI:InChI=1/C9H13NO/c1-8-4-2-3-5-9(8)11-7-6-10/h2-5H,6-7,10H2,1H3

Upstream product

• 95-48-7 ortho-cresol 
• 22560-43-6 ortho-methylphenoxyacetamide 
• 18800-32-3 1-(2-bromoethoxy)-2-methylbenzene 

Downstream Products

• 99860-87-4 trichloro-acetic acid-(2-o-tolyloxy-ethylamide) 
• 68250-88-4 2-(4-chloro-phenyl)-3-(2-o-tolyloxy-ethyl)-thiazolidin-4-one 
• 68250-60-2 2-phenyl-3-(2-o-tolyloxy-ethyl)-thiazolidin-4-one 
• 68250-70-4 2-(4-methoxy-phenyl)-3-(2-o-tolyloxy-ethyl)-thiazolidin-4-one 
• 68250-97-5 2-(2,4-dichloro-phenyl)-3-(2-o-tolyloxy-ethyl)-thiazolidin-4-one 
• 83722-35-4 2-{4-[2-Hydroxy-3-(2-(2-methyl-phenoxy)-ethylamino)-propoxy]-phenyl}-3-methyl-6,7-dimethoxy-3,4-dihydro-quinazolin-4-one 
• 72956-23-1 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methylphenoxy)ethyl]-amino}-2-propanol 

Relevant academic research and scientific papers

Design, synthesis, crystal structure, and herbicidal activity of novel pyrrolidine-2,4-dione derivatives incorporating an alkyl ether pharmacophore with natural tetramic acids as lead compounds

In order to discover green herbicides with novel molecular scaffolds, natural tetramic acids were used as lead compounds to design and synthesize four pyrrolidine-2,4-dione derivatives incorporating a chainlike alkoxyalkyl moiety (4a-4d) and nineteen pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety (10a-10s)viasubstitution, acylation, cyclization, and acidification reactions. The synthesized target compounds were confirmed by FT-IR,1H NMR,13C NMR and HRMS spectral analyses. The single-crystal structure of compound10awas analyzed by X-ray diffraction, which revealed that the 1-hydroxyethylidene group links the third position of the pyrrolidine heterocycle through a double bond with theZ-configuration. The herbicidal activity was evaluated using barnyard grass (Echinochloa crus-galli) and rape (Brassica campestris) as model plants by a Petri dish culture method. Most target compounds were found to possess moderate to good inhibitory activities against the plant growth at 100 μg mL?1. Among them, the compounds10qand10nshowed the highest herbicidal activities against the roots of barnyard grass and rape seedlings with the corresponding inhibition rates of 65.6% and 84.0%, respectively. This result indicated that pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety are worthy of further structural optimization.

Identification of N-(2-Phenoxyethyl)imidazo[1,2-a]pyridine-3-carboxamides as New Antituberculosis Agents

A series of imidazo[1,2-a]pyridine carboxamides (IPAs) bearing an N-(2-phenoxyethyl) moiety was designed and synthesized as new antitubercular agents. Seven 2,6-dimethyl IPAs demonstrated excellent in vitro activity (MIC: 0.025-0.054 μg/mL) against the drug susceptive H37Rv strain and two clinically isolated multidrug-resistant Mycobacterium tuberculosisstrains. Compound 10j displayed acceptable safety and pharmacokinetic properties, opening a new direction for further development.

Synthesis and pharmacological activity of a new series of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)-propan-2-ol analogs

β-Adrenergic receptor antagonists are important therapeutics for the treatment of cardiovascular disorders. In the group of β-blockers, much attention is being paid to the third-generation drugs that possess important ancillary properties besides inhibiting β-adrenoceptors. Vasodilating activity of these drugs is produced through different mechanisms, such as nitric oxide (NO) release, β2-agonistic action, α1-blockade, antioxidant action, and Ca2t entry blockade. Here, a study on evaluation of the cardiovascular activity of five new compounds is presented. Compound 3a is a methyl and four of the tested compounds (3b–e) are dimethoxy derivatives of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)-ethylamino)propan-2-ol. The obtained results confirmed that the methyl and dimethoxy derivatives of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and their enantiomers possess α1- and β1-adrenolytic activities and that the antiarrhythmic and hypotensive effects of the tested compounds are related to their adrenolytic properties.

Discovery of a new series of 5-HT1A receptor agonists

Starting from compounds previously identified as α1-adrenoceptor antagonists that were also found to bind to the 5-HT1A receptor, in an attempt to separate the two activities, a new series of 5-HT1A receptor agonists was identified and shown to have high potency and/or high selectivity. Of these, compound 13, which combines high selectivity (5-HT1A/α1 = 151) and good agonist potency (pD2 = 7.82; Emax = 76), was found to be the most interesting.

SUBSTITUTED 2H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS GSK-3 INHIBITORS

The invention relates to compounds of formula (I) prodrugs thereof, and the pahrmaceutically acceptabel salts of the compounds and prodrugs, wherein Ra, Rb, R1 and R2 are as defined herein; pharmaceutical compositions thereof; and uses thereof.

Phenoxypropanol connected with phenylpiperazine and phenoxyalkylamine terminal in its side chain

The invention disclosed some 1,4-dihydropiridine derivative chemically have pharmacologically with adrenoceptor blocking and calcium channel blocker is now emerging. The compound of 1,4-dihydropiridine derivative wherein has the formula I, wherein R selected from four group as follow whetherin R present R1 selected from halogen(X), hydrogen(H), saturated C1-C6 alkyl chain, saturated C1-C6 alkyoxyl chain, R2 selected from R3 selected from halogen(X), hydrogen(H), saturated C1-C6 alkyl chain, saturated C1-C6 alkyoxyl chain, and O—(C1-C3)—CF3.