26585-27-3Relevant academic research and scientific papers
Highly efficient synthesis of benzodioxins with a 2-site quaternary carbon structure by secondary amine-catalyzed dual Michael cascade reactions
He, Xuefeng,Li, Yongsu,Wang, Meng,Chen, Hui-Xuan,Chen, Bin,Liang, Hao,Zhang, Yaqi,Pang, Jiyan,Qiu, Liqin
, p. 5533 - 5538 (2018)
Salicylic acids and substituted ynones were employed as substrates to afford a class of valuable 4H-benzo[d][1,3]dioxin-4-ones with a 2-site quaternary carbon structure in up to 92% yield by secondary amine-catalyzed dual Michael cascade reactions under mild reaction conditions. The α,β-unsaturated ketone as the key intermediate in the cascade process was successfully separated and characterized. As a result, a new reaction route for ynone species is demonstrated, which is totally different from the existing allenamine activation model.
