26593-77-1Relevant academic research and scientific papers
Reactions of Primary and Secondary Amines with Fluoronitrene Generated from Isopropyl N,N-Difluorocarbamate
Klopotek, David L.,Hobrock, Brice G.,Kovacic, Peter,Jones, Martin B.
, p. 1665 - 1667 (2007/10/02)
Isopropyl N,N-difluorocarbamate deaminates primary amines, RNH2, affording RH, N2, RNHCO2-i-C3H7, and RNH2*HF.With secondary amines, dibenzylamine gives bibenzyl, whereas pyrrolidine yields a ring-expansion product, 2,3,4,5-tetrahydropyridazine.The reactions are consistent with the generation of fluoronitrene and subsequent production of the intermediates RN=NH from RNH2 and R2N=N from R2NH.The advantages of using isopropyl N,N-difluorocarbamate as a source of fluoronitrene are discussed.
