26608-34-4

Usage

Uses

Used in Photodynamic Therapy:
Etioporphyrin III is used as a photosensitizing agent for photodynamic therapy, specifically targeting and destroying cancer cells. Its strong absorption in the near-infrared region allows for effective treatment of cancerous tumors located deep within the body.
Used in Medical Imaging:
Etioporphyrin III is used as a contrast agent in medical imaging, enhancing the visualization of cancerous tissues and other abnormalities. Its near-infrared absorption properties contribute to improved imaging quality and diagnostic accuracy.
Used in Skin Treatments:
Etioporphyrin III is used in the treatment of various skin conditions, leveraging its photodynamic properties to target and eliminate affected cells. This application can be beneficial for conditions such as acne, psoriasis, and certain types of skin cancer.
Used in Drug Delivery Systems:
Further research and development are ongoing to explore the potential of etioporphyrin III in drug delivery systems. Its unique properties may enable the development of novel carriers for targeted drug delivery, improving the efficacy and bioavailability of therapeutic agents in treating various medical conditions, including cancer.

InChI:InChI=1/C32H38N4/c1-9-21-17(5)25-13-26-18(6)23(11-3)31(34-26)16-32-24(12-4)20(8)28(36-32)15-30-22(10-2)19(7)27(35-30)14-29(21)33-25/h13-16,33,36H,9-12H2,1-8H3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-

Upstream product

• 493-90-3 mesoporphyrin IX 
• 94827-38-0 4-ethyl-5-methoxymethyl-3-methylpyrrole-2-carboxylic acid 
• 4776-32-3 5-(5-bromomethyl-4-ethyl-3-methyl-2H-pyrrol-2-ylidenemethyl)-2-bromo-4-ethyl-3-methyl-1H-pyrrole hydrobromide 
• 49619-17-2 5'-bromo-3',4-diethyl-3,4',5-trimethyl-2,2'-dipyrromethenium bromide/perbromide 
• 114132-54-6 3,3'-diethyl-4,4',5-trimethyl-2,2'-dipyrromethenium bromide 
• 32928-30-6 3-ethyl-2-formyl-4-methylpyrrole 
• 31896-92-1 4-ethyl-3,5-dimethyl-pyrrole-2-carboxylic acid tert-butyl ester 
• 491-18-9 4-ethyl-2,3-dimethyl-1H-pyrrole 
• 7670-43-1 3,4'-diethyl-4,3'-dimethyl-1H,1'H-5,5'-methanediyl-bis-pyrrole-2-carboxylic acid 
• 3750-36-5 benzyl 5-(acetoxymethyl)-4-ethyl-3-methyl-1H-pyrrole-2-carboxylate 
• 100619-73-6 ethyl 5-acetoxymethyl-4-ethyl-3-methylpyrrole-2-carboxylate 
• 2199-47-5 ethyl 3,5-dimethyl-4-ethylpyrrole-2-carboxylate 
• 6250-80-2 4-ethyl-3,5-dimethylpyrrole-2-carbaldehyde 
• 517-22-6 2,4-dimethyl-3-ethyl-pyrrole 

Downstream Products

• 17825-86-4 3,4-dimethylmaleimide 
• 20189-42-8 3-ethyl-4-methyl-pyrrole-2,5-dione 
• 1072-87-3 citraconimide 
• 517-22-6 2,4-dimethyl-3-ethyl-pyrrole 
• 491-18-9 4-ethyl-2,3-dimethyl-1H-pyrrole 

Relevant academic research and scientific papers

The Identification of Deuteroetiohaem IX in Colorado Coal

Using paramagnetically-shifted 1H NMR spectroscopy of the dicyano-iron(III) complexes at 600 MHz as the principal tool, the identification of etiohaem III in Colorado coal is confirmed (1.63 μg g-1), and deuteroetiohaem IX (0.52 μg g-1/su

Syntheses of per-15N labeled etioporphyrins I-IV and a related tetrahydrobenzoporphyrin for applications in organic geochemistry and vibrational spectroscopy

Nitrogen-15 labeled pyrroles have been prepared from commercially available 15N glycine or sodium nitrite using the Barton-Zard, Knorr, and Kleinspehn approaches. These pyrroles were used as intermediates in the synthesis of per-15N labeled porphyrins needed for the analysis and assignment of vibrational spectra for sedimentary porphyrins. Etioporphyrin-I was prepared via pyrromethene intermediates, while etioporphyrins II-V and a related tetrahydrobenzoporphyrin were synthesized via stepwise routes involving the copper(II) mediated cyclization of a,c-biladienes as the key step. Detailed analyses of both the proton and carbon-13 NMR spectra provide nitrogen-15 coupling constants for these important structures.

Cyclotetramerization of modified Knorr pyrroles into porphyrins. A reinvestigation.

The tetramerization of 3-ethyl-4-methyl-5-(methoxymethyl)pyrrole derivatives into is reinvestigated.This study demonstaretes that in most cases the starting material were misidentified and that, under controlled conditions, the pyrrole redistribution reac

Bromination of Dipyrromethenes for Porphyrin Synthesis

5'-Bromo-5-(bromomethyl)-2,2'-dipyrromethenium bromides (1) and dimers were prepared in 90percent yield from 5'-unsubstituted (16), 5'-carboxy- (15),or 5'-bromo-5-methyl-2,2'-dipyrromethenium bromides (17) by treatment of the latter with bromine and trifluoroacetic acid in chlorocarbon solvents at room temperature.Dipyrromethenes (1) are important intermediates in the Johnson regioselective synthesis of porphyrins via biladienes (3).Improvements in porphyrin synthetic methodology are exemplified by the preparation of etioporphyrin III (4a) and mesoporphyrin II dimethyl ester (4b)