26624-38-4

Upstream product

• 186581-53-3 diazomethane 
• 3131-23-5 4-hydroxyestrone 
• 5976-62-5 3-methoxy-4-hydroxy-1,3,5 ⁽¹⁰⁾-estratrien-17-one 
• 58562-33-7 4-methoxyestrone 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 5976-62-5 3-methoxy-4-hydroxy-1,3,5 ⁽¹⁰⁾-estratrien-17-one 
• 5976-63-6 2-Hydroxyestrone 3-methyl ether 
• 126291-41-6 3,4-Dimethoxy-1-nitro-1,3,5(10)-estratrien-17-one 

Relevant academic research and scientific papers

SYNTHESIS AND PHOTOCHEMICAL REACTIONS OF NITROESTROGENS: POSSIBLE PHOTOAFFINITY LABELS OF ZERO LENGTH

The syntheses of 3,4-dimethoxy-1,3,5(1O)-estratrien-17-one and 4-bromo-3-methoxy-2-nitro-1,3,5(10)-estratrien-17-one are described and their photoreactions with amines and hydroxide ion studied.The possible usefulness of these new steroids as photoaffinity labels of zero length is discussed.

Methylation of catechol estrogen with diazomethane

Dynamic aspects of methylation of catechol estrogen with diazomethane were investigated by means of thin-layer chromatography. The methylation rate of the hydroxyl group at the C-3 position was almost the same as that of the C-2 hydroxyl group in the reaction of 2-hydroxyestrogen, and 2-3 times that of the C-4 hydroxyl group in the reaction of 4-hydroxyestrogen. In these experiments, the maximum yields of 2-methoxyestrone, 2-hydroxyestrone 3-methyl ether, 4-methoxyesterone and 4-hydroxyesterone 3-methyl ether were 32, 39, 13, and 70%, respectively. In addition, demethylation of catechol estrogen dimethyl ethers with boron tribromide and synthesis of 4-hydroxyestrone monomethyl ethers are described.