26627-36-1Relevant articles and documents
Cholesterol appended bis-1,2,3-triazoles as simple supramolecular gelators for the naked eye detection of Ag+, Cu2+ and Hg2+ ions
Ghosh, Kumaresh,Panja, Atanu,Panja, Santanu
, p. 3476 - 3483 (2016)
Cholesterol coupled bis-1,2,3-triazoles 1-3 have been synthesized and their gelation abilities are examined. Bis triazoles 1-3 form a gel from CHCl3-CH3OH (2: 1, v/v) mixture solvents. In contrast, compounds 4 and 5, which are devoid of triazoles, are unable to form a gel under similar conditions and thus validate the essential role of triazoles in gelation. While the gel phase of 1 detects Cu2+ ions by showing phase transformation from gel to sol, gels derived from 2 and 3 undergo disintegration in the presence of Ag+, Cu2+ and Hg2+ ions. Such phase changes corroborate the visual sensing of metal ions. Moreover, the fluorescence titration of 3 discriminates Cu2+, Hg2+ and Ag+ ions by exhibiting differential quenching.
Low molecular weight supramolecular dehydroepiandrosterone-based gelators: Synthesis and molecular modeling study
Zhikol, Oleg A.,Shishkina, Svitlana V.,Lipson, Victoria V.,Semenenko, Alexander N.,Mazepa, Alexander V.,Borisov, Alexander V.,Mateychenko, Pavel V.
, p. 13112 - 13121 (2019)
Three novel isomeric supramolecular dehydroepiandrosterone appended 1,2,3-triazole-based potential gelators were synthesized. Their ability to form gels in different solvents was studied experimentally as well as at the molecular level by means of molecul
Click chemistry as an efficient tool to access β-cyclodextrin dimers
Mourer, Maxime,Hapiot, Frédéric,Monflier, Eric,Menuel, Stéphane
, p. 7159 - 7163 (2008)
The Cu(I)-catalyzed azide-alkyne cycloaddition has enabled practical and efficient preparation of hydroxylated, permethylated and peracylated β-cyclodextrin dimers in good yields starting from mono-6-azido-β-cyclodextrin and ortho-, meta- or para-bis-(pro
Design, Synthesis, and Structural Optimization of Lycorine-Derived Phenanthridine Derivatives as Wnt/β-Catenin Signaling Pathway Agonists
Chen, Duo-Zhi,Jing, Chen-Xu,Cai, Jie-Yun,Wu, Ji-Bo,Wang, Sheng,Yin, Jun-Lin,Li, Xiao-Nian,Li, Lin,Hao, Xiao-Jiang
, p. 180 - 188 (2016)
Lycorine is a benzylphenethylamine-type alkaloid member of the Amaryllidaceae family. A lycorine derivative, HLY78, was previously identified as a new Wnt/β-catenin signaling pathway agonist that targets the DAX domain of axin. Herein, the structural opti
Synthesis of Polycyclic Chromene Cores through Gold (I)-Catalyzed Intramolecular Hydroarylation Reaction (IMHA)
Arcadi, Antonio,Fabrizi, Giancarlo,Fochetti, Andrea,Franzini, Roberta,Ghirga, Francesca,Goggiamani, Antonella,Iazzetti, Antonia,Marrone, Federico,Serraiocco, Andrea
, p. 1676 - 1687 (2021/03/16)
A regioselective gold (I)-catalyzed approach for the construction of polycyclic chromene cores has been developed. The reaction proceeds in good to excellent yields under mild condition with a broad range of substrates providing a simple and efficient too
Synthesis and characterization of novel phenoxy-substituted enediyne-triazole conjugates using click chemistry
Joshi, Mukesh C.
, p. 195 - 202 (2021/03/19)
Novel group of phenoxy-substituted enediyne-triazole conjugates were synthesized by Huisgen [3+2] cycloaddition reaction (Click chemistry) in aqueous media. It was observed that ene-diynes were stable in aqueous medium and open-air conditions.
A copper-catalyzed synthesis of aryloxy-tethered symmetrical 1,2,3-triazoles as potential antifungal agents targeting 14 α-demethylase
Deshmukh, Tejshri R.,Jadhav, Rohit G.,Khedkar, Vijay M.,Sangshetti, Jaiprakash N.,Sarkate, Aniket P.,Shingate, Bapurao B.,Tiwari, Shailee V.
supporting information, p. 13104 - 13118 (2021/08/03)
The search for potent therapeutic agents has prompted the design and synthesis of a library of twenty-six aryloxy-tethered and amide-linked symmetrical 1,2,3-triazoles (8a-z) using a copper(i)-catalyzed click chemistry approach. All the synthesized compounds have been screened for theirin vitroantifungal activity against four different fungal strains as well as the enzymatic study for the inhibition of 14 α-demethylase enzyme. The bioactivity results show that most of the synthesized compounds were found to be better antifungal agents as compared to Miconazole. Among them, compound8ashowed the most promising antifungal activity against all the tested fungal strains. Furthermore, the enzymatic study reveals that compounds8iand8oare the most promising inhibitors of the 14 α-demethylase enzyme. In support of these results, the molecular docking study of the synthesized molecules against the sterol 14 α-demethylase (CYP51) could provide the structural basis for the antifungal activity. These compounds have also been analyzed for the ADME properties.
Enantioselective Palladium-Catalyzed Hydrophosphinylation of Allenes with Phosphine Oxides: Access to Chiral Allylic Phosphine Oxides
Wang, Jun,Yang, Zhiping
supporting information, p. 27288 - 27292 (2021/11/17)
A Pd-catalyzed hydrophosphinylation of alkyl and aryl-oxyallenes with phosphine oxides has been developed for the efficient and rapid construction of a family of chiral allylic phosphine oxides with a diverse range of functional groups. This methodology was further applied in the facile construction of chiral 2H-chromene and later stage functionalization of cholesterol.
THERMOLYSIS-MEDIATED PROCESS FOR MANUFACTURING CHROMENES INTENDED FOR THE PREPARATION OF THERMOSETTING RESINS
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Paragraph 0056, (2021/01/29)
A process for manufacturing chromenes which are intended for the preparation of thermosetting resins, includes transforming an aromatic propargyl ether of general formula (I) into a chromene by flash vacuum thermolysis, at a temperature of between 300 and
GOLD-CATALYSED PROCESS FOR MANUFACTURING CHROMENES INTENDED FOR THE PREPARATION OF THERMOSETTING RESINS
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Paragraph 0066-0067, (2021/01/29)
A process for manufacturing chromenes intended for the preparation of thermosetting resins, includes transforming an aromatic propargyl ether of general formula (I) into a chromene by homogeneous gold(I) catalysis with the catalyst (acetonitrile)[(2-biphe
