266306-27-8

Upstream product

• 22381-56-2 2-benzylcyclohexane-1,3-dione 

Downstream Products

• 644985-04-6 4-[4-(2-benzyl-3-oxo-cyclohex-1-enylamino)-2-methyl-phenyl]-3-methyl-4-oxo-butyric acid methyl ester 
• 644985-05-7 4-[4-(2-benzyl-3-oxo-cyclohex-1-enylamino)-3-methyl-phenyl]-3-methyl-4-oxo-butyric acid methyl ester 
• 644985-07-9 4-[4-(2-benzyl-3-oxo-cyclohex-1-enylamino)-2-fluoro-phenyl]-3-methyl-4-oxo-butyric acid methyl ester 
• 644985-09-1 4-[4-(2-benzyl-3-oxo-cyclohex-1-enylamino)-2-chloro-phenyl]-3-methyl-4-oxo-butyric acid methyl ester 
• 644985-08-0 4-[4-(2-benzyl-3-oxo-cyclohex-1-enylamino)-3-fluoro-phenyl]-3-methyl-4-oxo-butyric acid methyl ester 
• 644985-06-8 4-[4-(2-benzyl-3-oxo-cyclohex-1-enylamino)-2-ethyl-phenyl]-3-methyl-4-oxo-butyric acid methyl ester 
• 644985-01-3 4-[4-(2-benzyl-3-oxo-cyclohex-1-enylamino)-2,5-difluoro-phenyl]-3-methyl-4-oxo-butyric acid methyl ester 

Relevant academic research and scientific papers

Palladium-catalyzed coupling of vinylogous amides with aryl halides: Applications to the synthesis of heterocycles

Described herein is the first example of the palladium-catalyzed coupling of vinylogous amides with aryl bromides and chlorides. The scope of this reaction with respect to the aryl component is investigated. Additionally, a tandem reaction sequence in which the above coupling is followed by an intramolecular Heck reaction is presented. These reactions can be applied to high-yielding, one-pot syntheses of nitrogen-containing heterocycles.