26634-51-5Relevant academic research and scientific papers
Hydroxynitrile lyase-catalyzed addition of HCN to 4-substituted cyclohexanones: Stereoselective preparation of tetronic acids
Effenberger, Franz,Roos, Juergen,Kobler, Christoph,Buehler, Holger
, p. 671 - 679 (2007/10/03)
The addition of HCN to 4-alkylcyclohexanones 1 to give cyanohydrins 2 is strongly catalyzed by hydroxynitrile lyases (HNLs). With PaHNL, from bitter almond, trans-addition occurs almost exclusively, yielding trans-2. With MeHNL, from cassava, cis-addition
cis-trans selectivity of enzyme-catalyzed additions to 4-substituted cyclohexanones - Correlation with the Prelog/Ringold model of enzymatic hydrogenation
Effenberger, Franz,Roos, Juergen,Kobler, Christoph
, p. 1876 - 1879 (2007/10/03)
The choice of enzyme is decisive: for the enzyme-catalyzed addition of HCN to 4-substituted cyclohexanones 1, highly selective biocatalysts are available that allow control to yield the cis or the trans addition product 2. Modeling of the S enzyme - subst
Approche de la syntese d'α-aminonitriles en milieu organique anhydre
Geneste, Patrick,Kamenka, Jean-Marc,Dessapt, Patrice
, p. 187 - 191 (2007/10/02)
A Strecker-like reaction in organic medium gives two isomeric α-aminonitriles in good yield.The influence of water and temperature on the isomeric ratio is discussed.Under quasi-kinetic conditions (anhydrous medium) the isomeric ratio is 60 40 minimum in favour of the non-thermodynamic product.If the imonium ion is the intermediate, there is preferential equatorial nucleophile attack rather than axial.
