26641-43-0Relevant academic research and scientific papers
Triple aryne-tetrazine reaction enabling rapid access to a new class of polyaromatic heterocycles
Suh, Sung-Eun,Barros, Stephanie A.,Chenoweth, David M.
, p. 5128 - 5132 (2015/08/24)
One of the most challenging goals of modern synthetic chemistry is to develop multi-step reactions for rapid and efficient access to complex molecules. We report a triple aryne-tetrazine reaction that enables rapid access to a new class of polyaromatic heterocycles. This new reaction, which couples diverse reactivity modes between simple aryne and tetrazine starting materials, proceeds in a single operation and takes less than 5 minutes in air with no metal catalyst.
