26645-35-2 Usage
Uses
Used in Cell Biology Research:
Phallacidin is used as a probe for studying the dynamics and organization of the cytoskeleton, specifically the actin filaments. Its ability to bind F-actin helps researchers visualize and analyze the structure and function of the cytoskeleton in various cell types.
Used in Biochemistry:
Phallacidin is used as a tool in biochemical studies to investigate the interactions between actin and other proteins or molecules. Its binding to F-actin allows researchers to explore the mechanisms of actin polymerization and depolymerization, as well as the role of actin in various cellular processes.
Used in Drug Development:
Phallacidin is used as a lead compound in the development of new drugs targeting the cytoskeleton and related cellular processes. Its ability to bind F-actin and promote actin polymerization makes it a potential candidate for the treatment of diseases associated with cytoskeletal dysfunction.
Used in Diagnostics:
Phallacidin is used as a diagnostic tool in the detection and analysis of cytoskeletal abnormalities in various diseases, such as cancer and neurodegenerative disorders. Its binding to F-actin enables the visualization of actin filaments, aiding in the identification of abnormal cytoskeletal structures.
Biochem/physiol Actions
Phallacidin, which is a bicyclic toxin from the Amanita phalloides mushroom, has been shown to inhibit F-actin degradation by proteolytic enzymes including trypsin and α-chymotrypsin.
Enzyme inhibitor
This cyclic heptapeptide toxin (FWfree-acid = 846.92 g/mol; CAS 26645-35-2) from the poisonous green fungus Amanita phalloides stabilizes actin filaments and inhibits actin filament depolymerization. NBD phallacidin is a high-affinity, filamentous actin probe consisting of rabbit actin that is conjugated by reacting its thiol group with 4-chloro-7- nitrobenzofurazan, a yellow-green fluorescent dye. NBD phallacidin (Excitation at 465 nm; Emission at 536 nm) selectively stains F-actin un a manner that is superior to antibody staining, preferably in fixed and permeabilized samples. See Phalloidin
Check Digit Verification of cas no
The CAS Registry Mumber 26645-35-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,6,4 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 26645-35:
(7*2)+(6*6)+(5*6)+(4*4)+(3*5)+(2*3)+(1*5)=122
122 % 10 = 2
So 26645-35-2 is a valid CAS Registry Number.
InChI:InChI=1/C36H48N8O12S/c1-15(2)25-31(51)43-26(35(54)55)32(52)40-23-13-57-33-19(18-7-5-6-8-20(18)41-33)10-21(28(48)39-22(29(49)42-25)11-36(4,56)14-45)38-27(47)16(3)37-30(50)24-9-17(46)12-44(24)34(23)53/h5-8,15-17,21-26,41,45-46,56H,9-14H2,1-4H3,(H,37,50)(H,38,47)(H,39,48)(H,40,52)(H,42,49)(H,43,51)(H,54,55)/t16-,17?,21-,22-,23-,24-,25?,26-,36-/m0/s1
