26646-46-8

Usage

Structure

An amine derivative with a phenoxy group and two methyl substituents attached to the phenyl ring

Usage

Commonly used in the synthesis of pharmaceuticals and agrochemicals

Applications

Has a variety of applications in organic chemistry, including as an intermediate in the production of various bioactive compounds

Importance

A valuable building block for the development of new drugs and other functional molecules

InChI:InChI=1/C10H15NO/c1-8-5-9(2)7-10(6-8)12-4-3-11/h5-7H,3-4,11H2,1-2H3

Upstream product

• 33901-47-2 (3,5-dimethylphenoxy)acetonitrile 
• 108-68-9 3,5-Dimethylphenol 

Downstream Products

• 316128-77-5 N-[2-(3,5-dimethylphenoxy)ethyl]benzamide 
• 428840-42-0 N-[2-(3,5-dimethylphenoxy)ethyl]-4-nitrobenzamide 
• 1443148-08-0 N-[2-(3,5-dimethylphenoxy)ethyl]acetamide 
• 1443148-10-4 6,8-dimethyl-5-phenyl-2,3-dihydro-1,4-benzoxazepine 
• 1443148-11-5 6,8-dimethyl-5-(4-nitrophenyl)-2,3-dihydro-1,4-benzoxazepine 
• 1443148-14-8 4,6,8-trimethyl-5-phenyl-2,3-dihydro-1,4-benzoxazepinium iodide 
• 1443148-15-9 4,6,8-trimethyl-5-(4-nitrophenyl)-2,3-dihydro-1,4-benzoxazepinium iodide 
• 1443148-18-2 4,6,8-trimethyl-5-phenyl-2,3,4,5-tetrahydro-1,4-benzoxazepine 
• 1443148-19-3 4,6,8-trimethyl-5-(4-nitrophenyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine 
• 1443148-22-8 methyl (2E)-3-[{2-[2-(1-methoxyethyl)-3,5-dimethylphenoxy]ethyl}methylamino]acrylate 
• 1443148-23-9 methyl (2E)-3-[(2-{2-[methoxy(phenyl)methyl]-3,5-dimethylphenoxy}ethyl)(methyl)amino]acrylate 
• 1443148-24-0 methyl (2E)-3-[(2-{2-[methoxy(4-nitrophenyl)methyl]-3,5-dimethylphenoxy}ethyl)(methyl)amino]-acrylate 

Relevant academic research and scientific papers

Design, synthesis, crystal structure, and herbicidal activity of novel pyrrolidine-2,4-dione derivatives incorporating an alkyl ether pharmacophore with natural tetramic acids as lead compounds

In order to discover green herbicides with novel molecular scaffolds, natural tetramic acids were used as lead compounds to design and synthesize four pyrrolidine-2,4-dione derivatives incorporating a chainlike alkoxyalkyl moiety (4a-4d) and nineteen pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety (10a-10s)viasubstitution, acylation, cyclization, and acidification reactions. The synthesized target compounds were confirmed by FT-IR,1H NMR,13C NMR and HRMS spectral analyses. The single-crystal structure of compound10awas analyzed by X-ray diffraction, which revealed that the 1-hydroxyethylidene group links the third position of the pyrrolidine heterocycle through a double bond with theZ-configuration. The herbicidal activity was evaluated using barnyard grass (Echinochloa crus-galli) and rape (Brassica campestris) as model plants by a Petri dish culture method. Most target compounds were found to possess moderate to good inhibitory activities against the plant growth at 100 μg mL?1. Among them, the compounds10qand10nshowed the highest herbicidal activities against the roots of barnyard grass and rape seedlings with the corresponding inhibition rates of 65.6% and 84.0%, respectively. This result indicated that pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety are worthy of further structural optimization.

Transformations of tetrahydro-1,4-benzoxazepines and tetrahydro-1,4- benzothiazepines under the action of alkynes. First example of the synthesis of tetrahydro-1,4-benzothiazonine-6-carboxylate

It was shown that 2,3,4,5-tetrahydro-1,4-benzoxazepines were cleaved at the N-C(5) bond under the action of activated alkynes in methanol, forming o-(methoxyethyl)- and o-(methoxybenzyl)-phenyl(aminoethyl) ethers. The cleavage rate depended on the electro