Cas 266682-85-3,(S)-2-tert-Butoxycarbonylamino-3-(4-{((S)-1-methoxycarbonyl-ethylamino)-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethoxy]-phosphoryloxy}-phenyl)-propionic acid methyl ester

266682-85-3

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Basic information

Product Name: (S)-2-tert-Butoxycarbonylamino-3-(4-{((S)-1-methoxycarbonyl-ethylamino)-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethoxy]-phosphoryloxy}-phenyl)-propionic acid methyl ester
Synonyms:
CAS NO:266682-85-3
Molecular Formula:
Molecular Weight: 666.622
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (S)-2-tert-Butoxycarbonylamino-3-(4-{((S)-1-methoxycarbonyl-ethylamino)-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethoxy]-phosphoryloxy}-phenyl)-propionic acid methyl ester(CAS DataBase Reference)
NIST Chemistry Reference: (S)-2-tert-Butoxycarbonylamino-3-(4-{((S)-1-methoxycarbonyl-ethylamino)-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethoxy]-phosphoryloxy}-phenyl)-propionic acid methyl ester(266682-85-3)
EPA Substance Registry System: (S)-2-tert-Butoxycarbonylamino-3-(4-{((S)-1-methoxycarbonyl-ethylamino)-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethoxy]-phosphoryloxy}-phenyl)-propionic acid methyl ester(266682-85-3)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 266682-85-3(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 266682-85-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,6,6,8 and 2 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 266682-85:
(8*2)+(7*6)+(6*6)+(5*6)+(4*8)+(3*2)+(2*8)+(1*5)=183
183 % 10 = 3
So 266682-85-3 is a valid CAS Registry Number.

266682-85-3Upstream product

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266682-85-3Relevant academic research and scientific papers

Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs

Siddiqui, Adam,McGuigan, Christopher,Ballatore, Carlo,Srinivasan, Sheila,De Clercq, Erik,Balzarini, Jan

, p. 381 - 384 (2000)

A range of polyether para-substituted phosphoramidates were synthesised and found to have substantially elevated aqueous solubilities compared to the underivatised parent prodrug. A 30-fold increase in aqueous solubility could be achieved without a substantial decrease of in vitro activity against HIV-1. Replacement of the aryl (i.e. phenolic) moiety by tyrosine led to a substantial enhancement in aqueous solubility but also to a decrease in antiviral potency. A previously unobserved trend was identified, relating increased aryl substituent steric bulk to decreased antiviral activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

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