266682-92-2

Upstream product

• 2491-20-5 L-alanine methyl ester hydrochloride 
• 266682-88-6 C₁₃H₁₉Cl₂O₆P 
• 186365-71-9 4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenol 
• 123-31-9 hydroquinone 
• 112-35-6 triethylene glucol monomethyl ether 

Relevant academic research and scientific papers

Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs

A range of polyether para-substituted phosphoramidates were synthesised and found to have substantially elevated aqueous solubilities compared to the underivatised parent prodrug. A 30-fold increase in aqueous solubility could be achieved without a substantial decrease of in vitro activity against HIV-1. Replacement of the aryl (i.e. phenolic) moiety by tyrosine led to a substantial enhancement in aqueous solubility but also to a decrease in antiviral potency. A previously unobserved trend was identified, relating increased aryl substituent steric bulk to decreased antiviral activity. (C) 2000 Elsevier Science Ltd. All rights reserved.