26686-10-2Relevant academic research and scientific papers
The synthesis of new oxindoles as analogs of natural product 3,3′-bis(indolyl)oxindole and in vitro evaluation of the enzyme activity of G6PD and 6PGD
Bayindir, Sinan,Ayna, Adnan,Temel, Yusuf,?iftci, Mehmet
, p. 332 - 345 (2018)
Natural and synthetic derivatives that contain an indole core are being used in medical treatments and technological processes. Therefore, the development of new synthetic methods for the synthesis of indole derivatives is very popular. In this study, new
Non-Cryogenic, Ammonia-Free Reduction of Aryl Compounds
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, (2022/03/31)
A method of reducing an aromatic ring or a cyclic, allylic ether in a compound includes preparing a reaction mixture including a compound including an aromatic moiety or a cyclic, allylic ether moiety, an alkali metal, and either ethylenediamine, diethylenetriamine, triethylenetetramine, or a combination thereof, in an ether solvent; and reacting the reaction mixture at from ?20° C. to 30° C. for a time sufficient to reduce a double bond in the aromatic moiety to a single bond or to reduce the cyclic, allylic ether moiety.
Impacts of dibenzo- and dithieno-fused structures at the b, g bonds in the bodipy skeleton
Shimogawa, Hiroyuki,Mori, Haruki,Wakamiya, Atsushi,Murata, Yasujiro
supporting information, p. 986 - 988 (2013/09/24)
Dibenzo[b,g]-fused and dithieno[b,g]-fused BODIPY derivatives were synthesized, and the electronic effects of the introducing dibenzo- and dithieno-fused structures at both of the b and g bonds in the BODIPY skeleton were investigated. Electrochemical and
Pyrrolovesamicols - Synthesis, structure and VAChT binding of two 4-fluorobenzoyl regioisomers
Wenzel, Barbara,Li, Yan,Kraus, Werner,Sorger, Dietlind,Sabri, Osama,Brust, Peter,Steinbach, J?rg
scheme or table, p. 2163 - 2166 (2012/05/04)
This Letter describes the synthesis of two regioisomers of a new class of vesamicol analogs as possible ligands for imaging the vesicular acetylcholine transporter in future PET studies. The two pyrrolovesamicols (±)-6a and (±)-6b were synthesized by nucl
Enantioselective synthesis of tertiary alcohols through a zirconium-catalyzed Friedel-Crafts alkylation of pyrroles with α-ketoesters
Blay, Gonzalo,Fernandez, Isabel,Munoz, M. Carmen,Pedro, Jose R.,Recuenco, Alejandro,Vila, Carlos
body text, p. 6286 - 6294 (2011/10/01)
Chiral complexes of 1,1′-bi-2-naphthol-based ligands with zirconium tert-butoxide catalyze the Friedel-Crafts alkylation of pyrroles with α-ketoesters to afford tertiary alcohols in good yields and ee up to 98%. The reaction is also of application to 4,7-dihydroindole to give C2-alkylated indoles after oxidation with p-benzoquinone.
Synthesis of a new series of 2-vinylindoles and their cycloaddition reactivity
Arslan, Tayfun,Sadak, Ali Enis,Saracoglu, Nurullah
body text, p. 2936 - 2939 (2010/06/20)
The regioselective synthesis of 2-vinylindoles was achieved through the use of 4,7-dihydroindole 19. Reactions of these 2-vinylindoles as 4π-component gave 2,3-disubstitue indoles as well as the expected Diels-Alder products.
A new approach for the synthesis of 2-substituted indole derivatives via Michael type adducts
?avdar, Hüseyin,Sara?o?lu, Nurullah
, p. 2401 - 2405 (2007/10/03)
4,7-Dihydroindole undergoes regioselective alkylation at the 2-position of the indole nucleus through conjugate addition with α,β-unsaturated carbonyl compounds. The oxidation of the Michael adducts affords the corresponding 2-substituted indole derivatives which were characterized by spectroscopic methods.
Reduction of the indole ring system: Synthesis of 4,5,6,7-tetrahydroindoles
McComas, Casey C.,Van Vranken, David L.
, p. 8039 - 8043 (2007/10/03)
A general two-step procedure for the reduction of indoles to the corresponding 4,5,6,7-tetrahydroindoles has been developed. A regioselective Birch reduction followed by catalytic hydrogenation is employed to accomplish this transformation. Yields for the sensitive pyrrole products are typically between 40 and 50%. This method provides access to complex chiral pyrroles that cannot be readily prepared by other methods.
