267013-77-4 Usage
Uses
Used in Pharmaceutical Synthesis:
(R)-(-)-2-Hydroxy-4-phenylbutyric acid is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the chiral properties of the final drug products, which can influence their efficacy and safety.
Used in Asymmetric Synthesis:
As a chiral auxiliary, (R)-(-)-2-Hydroxy-4-phenylbutyric acid is employed in asymmetric synthesis to induce a specific stereochemistry in the target molecule, enhancing the selectivity and yield of enantioselective reactions.
Used in Organic Synthesis:
(R)-(-)-2-Hydroxy-4-phenylbutyric acid serves as a versatile building block in organic synthesis, contributing to the creation of complex organic molecules with specific stereochemical configurations.
Used in Therapeutic Research:
In the field of medicine, (R)-(-)-2-Hydroxy-4-phenylbutyric acid is studied for its potential therapeutic effects, particularly in the treatment of mental health conditions such as schizophrenia and bipolar disorder, where its stereochemistry may play a role in modulating the activity of neurotransmitters or other biological targets.
Check Digit Verification of cas no
The CAS Registry Mumber 267013-77-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,7,0,1 and 3 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 267013-77:
(8*2)+(7*6)+(6*7)+(5*0)+(4*1)+(3*3)+(2*7)+(1*7)=134
134 % 10 = 4
So 267013-77-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H12O3/c11-9(10(12)13)7-6-8-4-2-1-3-5-8/h1-5,9,11H,6-7H2,(H,12,13)/t9-/m1/s1
267013-77-4Relevant academic research and scientific papers
Chikusa, Yasuo,Fujimoto, Taizo,Ikunaka, Masaya,Inoue, Toru,Kamiyama, Shunji,Maruo, Koichi,Matsumoto, Jun,Matsuyama, Keisuke,Moriwaki, Masafumi,Nohira, Hiroyuki,Saijo, Shigeya,Yamanishi, Masato,Yoshida, Kazuto
, p. 291 - 296 (2002)
(S)-Ibuprofen 2, (S)-ketoprofen 3, and (S)-naproxen 4 are all obtained by optical resolution of the respective racemates with (S)-3-methyl-2-phenylbutylamine (PBA) 1: (S)-2, 98.7% ee, 39.8% yield; (S)-3, 99.4% ee, 36.7% yield; (S)-4, 99.2% ee, 35.1% yield. (S)-PBA 1 is also useful in resolving other racemic carboxylic acids of pharmaceutical importance; (R)-2-hydroxy-4-phenylbutanoic acid (HPBA) 5, a key intermediate for ACE inhibitors such as benazapril 7, and (S)-2-benzylsuccinic acid (BSA) 6, a key intermediate for hypoglycemic KAD-1229 8, are obtained in 99% ee and 34.4% yield, and in 99% ee and 32.2% yield, respectively.
