26706-43-4

Upstream product

• 10401-11-3 3-hydroxy phenylacetylene 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 2200-91-1 4-ethynylphenol 
• 54673-07-3 α-cyano-3-hydroxycinnamic acid 
• 372-09-8 cyanoacetic acid 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 23941-90-4 (E)-3-(3-Hydroxy-phenyl)-acrylimidic acid methyl ester; hydrochloride 
• 1333950-28-9 C₂₂H₁₇N₇O 
• 1333950-27-8 C₂₃H₁₈N₆O₂ 
• 1333950-26-7 C₂₁H₁₆N₆O₃ 
• 1333950-15-4 C₂₃H₁₇N₅O 
• 1333950-14-3 C₂₃H₁₉N₅O 
• 1333950-13-2 C₂₁H₁₅N₅OS 
• 1333950-12-1 C₂₂H₁₇N₅O 
• 1333950-11-0 C₂₁H₁₅N₅O₂ 
• 1333950-38-1 (E)-4-((4-chloro-6-cyclopropyl-1,3,5-triazin-2-yl)amino)-2-(3-(2-cyanovinyl)phenoxy)benzonitrile 
• 1333950-37-0 C₂₀H₁₃ClN₆O₂ 
• 1333950-39-2 C₁₆H₁₁N₃O 
• 1333950-29-0 C₂₂H₁₆N₆O 

Relevant academic research and scientific papers

PROCESS FOR HYDROCYANATION OF TERMINAL ALKYNES

The present invention refers to a process for a Rh-catalyzed Anti-Markovnikov hydrocyanation of terminal alkynes which process discloses, for the first time, the highly stereo- and regio-selective hydrocyanation of terminal alkynes to furnish E- configured alkenyl nitriles and the catalyst used in the present process.

Rh-Catalyzed Anti-Markovnikov Hydrocyanation of Terminal Alkynes

We report the first highly stereo- and regioselective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles. Acrylonitriles can be accessed on gram scale with broad substrate scope and functional group tolerance. The hydrocyanation reaction employs acetone cyanohydrin as a practical alternative to HCN gas.