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267220-45-1

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267220-45-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 267220-45-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,7,2,2 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 267220-45:
(8*2)+(7*6)+(6*7)+(5*2)+(4*2)+(3*0)+(2*4)+(1*5)=131
131 % 10 = 1
So 267220-45-1 is a valid CAS Registry Number.

267220-45-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-oxa-2-azabicyclo[2.2.2]oct-5-ene-2-carboxamide

1.2 Other means of identification

Product number -
Other names 2-Oxa-3-azabicyclo[2.2.2]oct-5-ene-3-carboxamide(9CI)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:267220-45-1 SDS

267220-45-1Downstream Products

267220-45-1Relevant articles and documents

Catalase-mediated nitric oxide formation from hydroxyurea

Huang, Jinming,Kim-Shapiro, Daniel B.,King, S. Bruce

, p. 3495 - 3501 (2004)

Hydroxyurea reduces the incidence of painful crises in patients with sickle cell disease and has recently been approved for the treatment of this condition. A number of in vitro studies show that the oxidation of hydroxyurea results in the formation of nitric oxide, which also has drawn considerable interest as a sickle cell disease therapy. While patients on hydroxyurea demonstrate elevated levels of nitric oxide-derived metabolites, little information regarding the site or mechanism of the in vivo conversion of hydroxyurea to nitric oxide exists. Chemiluminescence detection experiments show the ability of catalase to catalyze the formation of nitrite and nitrate from hydroxyurea. Spectroscopic studies show that the reaction of hydroxyurea and catalase in the presence of a hydrogen peroxide generating system produces a ferrous-NO catalase complex. Trapping studies indicate the intermediacy of a nitroso species during this reaction. The proposed mechanism for this conversion includes initial hydrogen peroxide-dependent oxidation of hydroxyurea by catalase to form the nitroso species, hydrolysis of this nitroso species to produce nitroxyl, and reductive nitrosylation of the ferric heme of catalase by nitroxyl to yield the ferrous-NO catalase complex. Addition of Angeli's salt, a nitroxyl donor, to ferric catalase also produces the ferrous-NO catalase complex. Spectroscopic studies show that the ferrous-NO catalase complex releases nitric oxide as judged by the oxyhemoglobin assay and an NO specific EPR specific trap. These results demonstrate nitric oxide production from the ferric catalase oxidation of nitroxyl and identify a catalase-mediated pathway as a potential source of nitric oxide production from hydroxyurea.

Production of nitroxyl (HNO) at biologically relevant temperatures from the retro-Diels-Alder reaction of N-hydroxyurea-derived acyl nitroso-9,10- dimethylanthracene cycloadducts

Xu, Yueping,Alavanja, Maria-Michelle,Johnson, Veta L.,Yasaki, Genichiro,King, S. Bruce

, p. 4265 - 4269 (2000)

Retro Diels-Alder reaction of N-hydroxyurea-derived acyl nitroso compound-9,10-dimethylanthracene cycloadducts produce acyl nitroso compounds that react with nucleophiles to form nitrous oxide, which indicates the intermediacy of nitroxyl. These results identify these molecules as a new group of nitroxyl delivery agents. (C) 2000 Elsevier Science Ltd.

Generation of acyl nitroso compounds by the oxidation of N-acyl hydroxylamines with the Dess-Martin periodinane

Jenkins, Neil E.,Ware Jr., Roy W.,Atkinson, Robert N.,King, S. Bruce

, p. 947 - 953 (2007/10/03)

The oxidation of hydroxamic acids, N-hydroxyureas and N- hydroxycarbamates with the Dess-Martin periodinane generates the corresponding acyl nitroso compounds that react with conjugated dienes to produce the corresponding cycloadducts.

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