26723-60-4 Usage
Uses
Used in Pharmaceutical Industry:
3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide is used as an intermediate in the synthesis of Dibenzo[c,f][1,2]thiazepine derivatives for the pharmaceutical industry. These derivatives are known for their diverse biological activities, including potential applications in the development of new drugs for various therapeutic areas.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide serves as a key building block for the creation of more complex molecules with specific properties. Its unique structure allows for further functionalization and modification, making it a valuable starting material for the synthesis of novel compounds with potential applications in various industries, such as materials science, agrochemicals, and pharmaceuticals.
Used in Research and Development:
3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide is also utilized in research and development settings, where it can be employed to study the structure-activity relationships of dibenzothiazepine derivatives. This knowledge can be applied to optimize the properties of these compounds for specific applications, such as improving their pharmacological profiles or enhancing their stability and solubility.
Check Digit Verification of cas no
The CAS Registry Mumber 26723-60-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,7,2 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 26723-60:
(7*2)+(6*6)+(5*7)+(4*2)+(3*3)+(2*6)+(1*0)=114
114 % 10 = 4
So 26723-60-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H12ClNO3S/c1-16-12-5-3-2-4-10(12)14(17)11-7-6-9(15)8-13(11)20(16,18)19/h2-8,14,17H,1H3
26723-60-4Relevant academic research and scientific papers
NOVEL PROCESS FOR THE PREPARATION OF 7-((3-CHLORO-6-METHYL-5,5-DIOXO-6,11-DIHYDRODIBENZO(C,F)(1,2) THIAZEPIN-11-YL)AMINO)HEPTANOATE
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Page/Page column 5, (2010/08/05)
The present invention relates to a novel process for the preparation of sodium 7-((3-Chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate and intermediates. The invention also encompasses isolation of an essentially non-hygroscopic compound which is substantially pure.
New Triazine Derivatives as Potent Modulators of Multidrug Resistance
Dhainaut, Alain,Regnier, Gilbert,Atassi, Ghanem,Pierre, Alain,Leonce, Stephane,et al.
, p. 2481 - 2496 (2007/10/02)
A series of 70 triazine derivatives have been synthesized and tested for their capacity to modulate multidrug resistance (MDR) in DC-3F/AD and KB-A1 tumor cells in vitro, in comparison with verapamil (VRP), a calcium channel antagonist currently used in therapy as an antihypertensive drug, which also shows MDR modulating activity.Among the 12 selected compounds, 16 (S9788) showed high MDR reversing properties in vitro (300- and 6-fold VRP at 5μM in DC-3F/AD and KB-A1 cells, respectively) and induced a strong accumulation of adriamycin.The relationship between the increase of ADR accumulation and the fold reversal induced by these compounds and their lack of effects on the sensitive DC-3F cells suggest that they act mainly by inhibiting the P-glycoprotein (Pgp) catalyzed efflux of cytotoxic agents, as already described for a majority of MDR modulators.In vivo, in association with the antitumor drug vincristine (0.25 mg/kg), 16 (100 mg/kg) increased the T/C by 39percent in mice bearing the resistant tumor cell line P388/VCR.According to these interesting properties, 16 was selected for a clinical development because it is more bioavailable than 34, even though it was less active.
