26727-22-0

Basic information

• Product Name: H-GAMMA-ABU-OBZL P-TOSYLATE
• Synonyms: H-GAMMA-ABU-OBZL P-TOSYLATE;H-GAMMA-ABU-OBZL TOS-OH;H-ABU(4)-OBZL TOS-OH;GAMMA-AMINOBUTYRIC ACID BENZYL ESTER P-TOSYLATE;GAMMA-AMINOBUTYRIC ACID-OBZL P-TOSYLATE;γ-Aminobutyric acid benzyl ester p-tosylate;Hγ-Abu-OBzl·p-tosylate;H-g-Abu-OBzl·TosOH
• CAS NO: 26727-22-0
• Molecular Formula: C₇H₇O₃S*C₁₁H₁₆NO₂
• Molecular Weight: 365.44
• Mol File: 26727-22-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: H-GAMMA-ABU-OBZL P-TOSYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: H-GAMMA-ABU-OBZL P-TOSYLATE(26727-22-0)
• EPA Substance Registry System: H-GAMMA-ABU-OBZL P-TOSYLATE(26727-22-0)

Safety Data

• Hazardous Substances Data: 26727-22-0(Hazardous Substances Data)

Usage

General Description

H-GAMMA-ABU-OBZL P-TOSYLATE is a chemical compound that is also known as N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-γ-aminobutyric acid p-tosylate. It is often used in biochemical research and pharmaceutical development as a protecting group for amino acids in peptide synthesis. The compound has a tosylate group, which is a common leaving group in organic chemistry, attached to the gamma position of the amino acid, making it a useful intermediate in solid-phase peptide synthesis. Additionally, the fluorenylmethoxycarbonyl (FMOC) group provides stability and protection for the amino acid during the synthesis process. Overall, H-GAMMA-ABU-OBZL P-TOSYLATE is a valuable tool in the production of peptide-based drugs and the study of bioactive peptides.

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 100-51-6 benzyl alcohol 
• 56-12-2 4-amino-n-butyric acid 

Downstream Products

• 112579-59-6 Z-Val-γAbu-OBzl 
• 112559-24-7 Z-Leu-γAbu-OBzl 
• 112559-20-3 Z-Tyr(OBzl)-γAbu-OBzl 
• 112559-25-8 Z-Ala-γAbu-OBzl 
• 112559-23-6 Z-Ile-γAbu-OBzl 
• 88115-72-4 Z-Phe-γAbu-OBzl 
• 112559-22-5 Z-Ser-γAbu-OBzl 
• 112559-21-4 Z-Thr-γAbu-OBzl 
• 112559-19-0 Z-Hyp-γAbu-OBzl 
• 113332-42-6 Z-Asp(OBzl)-γAbu-OBzl 
• 158665-24-8 benzyl 4-amino>butylate 

Relevant articles and documents

DIPEPTIDE MIMETICS OF NGF AND BDNF NEUROTROPHINS

The invention relates to compounds having either agonist or antagonist activities for the neurotrophins NGF and BDNF and represented by monomeric or dimeric substituted dipeptides that are analogs of the exposed portions of loop 1 or loop 4 regions of these neurotrophins near or at a beta-turn of the respective loop. N-acylated substituents of these dipeptides are biostereoisomers of the amino acid residues preceding these dipeptide sequences in the neurotrophin primary structure. The dimeric structure is produced advantageously by using hexatnethylenediaanine to which dipeptides are attached via their carboxyl groups. The claimed compounds displayed neuroprotective and differentiation-inducing activities in cellular models and enhanced the amount of phosphorylated tyrosine kinase A and the heat shock proteins Hsp32 and Hsp70 in the concentration range of 10 -9 to 10 -5 M. They also displayed neuroprotective, anti-parkinsonian, anti-stroke, anti-ischemic, anti-depressant and anti-amnestic activities in animal models and were active in experimental models of Alzheimer's disease. These in vivo effects of the claimed compounds are displayed in the dose range of 0.01 to 10 mg/kg when administered intraperitoneally.

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