26737-96-2Relevant academic research and scientific papers
METHODS OF INHIBITING BACTERIAL VIRULENCE AND COMPOUNDS RELATING THERETO
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, (2017/01/31)
The present invention relates to compounds and methods for the treatment of bacterial infections. Because their mechanism of action does not involve killing of bacteria or inhibiting their growth, the potential for these compounds to induce drug resistance in bacteria is minimized. Through inhibiting bacterial virulence, the present invention provides a novel means of treating bacterial infections.
An 'inside-out' approach to suramin analogues
McGeary, Ross P.,Bennett, Andrew J.,Tran, Quoc B.,Prins, Johannes,Ross, Benjamin P.
experimental part, p. 3990 - 3997 (2009/10/09)
An approach to the synthesis of suramin analogues has been realised, which avoids synthetic problems associated with conventional routes. The use of isobutyl ester protecting groups for sulfonic acids was crucial to the success of the strategy, because these were able to be cleanly deprotected with sodium iodide, yielding the sodium salts of the corresponding sulfonic acids.
