2674-47-7Relevant academic research and scientific papers
Synthesis of Spiro annelated isochromanones by ring expansion of benzocyclobutenones in the presence of lithium diisopropylphosphide
Kohser, Stefanie C.,Gopal Dongol, Krishna,Butenschoen, Holger
, p. 339 - 350 (2008/09/17)
spiro-Annelated isochromanones are prepared by treatment of benzo-cyclobutenone with lithium diisopropylphosphide - borane adduct (LDP-BH3), which is easily accessible by metalation of the air stable diisopropylphos-phane-borane adduct. The reaction takes place at very mild reaction conditions and involves an oxyanion driven ring opening. As a substituted example the synthesis of the first trifluoromethyl-substituted isochromanone derivative is reported.
