267401-33-2 Usage
Uses
Used in Pharmaceutical Industry:
(R)-2-Acetamido-2-(2-fluorophenyl)propanoic acid is used as a starting material for the synthesis of various pharmaceuticals. Its unique structure and reactivity allow for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the chemical industry, (R)-2-Acetamido-2-(2-fluorophenyl)propanoic acid is utilized as a building block for the synthesis of a wide range of organic compounds. Its versatility in reactions enables the creation of diverse molecules with specific properties for various applications.
Used in Chiral Chemistry:
Due to its chiral nature, (R)-2-Acetamido-2-(2-fluorophenyl)propanoic acid is employed in chiral chemistry for the synthesis of enantiomerically pure compounds. This is crucial in the development of drugs with improved efficacy and reduced side effects, as the stereochemistry of a molecule can significantly impact its biological activity.
Used in Research and Development:
(R)-2-Acetamido-2-(2-fluorophenyl)propanoic acid serves as a valuable research tool in the study of chemical reactions and mechanisms. Its unique properties allow scientists to explore new reaction pathways and develop innovative synthetic methods, further expanding the scope of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 267401-33-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,7,4,0 and 1 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 267401-33:
(8*2)+(7*6)+(6*7)+(5*4)+(4*0)+(3*1)+(2*3)+(1*3)=132
132 % 10 = 2
So 267401-33-2 is a valid CAS Registry Number.
267401-33-2Relevant academic research and scientific papers
Water soluble phosphines: Part XIII. Chiral phosphine ligands with amino acid moieties
Brauer, David J.,Schenk, Stefan,Ro?enbach, Stefan,Tepper, Michael,Stelzer, Othmar,H?usler, Thomas,Sheldrick, William S.
, p. 116 - 126 (2007/10/03)
Nucleophilic phosphination of the potassium or sodium salt of the fluorophenylalanines (1a, 2a) or -glycines (3a, 4a) with potassium phosphides Ph(R)PK (R=Me, Ph) yields chiral phosphine ligands (1-7) with amino acid moieties. The X-ray structure of 3·2H2O (space group Pbca) has been determined showing a betaine type structure for the amino acid moiety. The α-methyl derivatives of the phosphinophenylglycines (10, 11) were obtained in an analogous manner as 1-7. ortho- and para-Fluoroacetophenones have been employed as starting material for the syntheses of α-[4-fluorophenyl]-α-methylglycine (9c) and its ortho-isomer (8c), the X-ray structure of its monohydrate has been determined (space group P1?). The N-acetyl (3b, 8e) and ester derivatives (3d, 8d) of 3 and 8c are accessible using standard procedures. Resolution of the diastereomeric salt 12 obtained from (S)-(+)-2-hydroxymethylpyrrolidine and racem-8e by fractionated crystallization yielded the (S,R)-isomer. The absolute configuration of (S,R)-12 was determined by X-ray structural analysis (space group P212121). Cleavage of (S,R)-12 with hydrochloric acid gave enantiopure (R)-8e [α]D20=-30.9° (c=1, CH3OH).
