267402-33-5Relevant academic research and scientific papers
Synthesis of highly epimerizable N-protected α-amino aldehydes of high enantiomeric excess
Myers, Andrew G.,Zhong, Boyu,Movassaghi, Mohammad,Kung, Daniel W.,Lanman, Brian A.,Kwon, Soojin
, p. 1359 - 1362 (2000)
The Dess-Martin periodinane was found to be a superior oxidant for the efficient, epimerization-free synthesis of optically active N-protected α- amino aldehydes from the corresponding N-protected β-amino alcohols. Highly racemization-prone products, including N-Fmoc phenylglycinal and N- trifluoroacetyl α-amino aldehydes, were prepared in ≥95% yield with ≤ 1% epimerization. (C) 2000 Elsevier Science Ltd.
