26750-81-2 Usage
Chemical Properties
White Solid
Originator
Cebera ,Bouchara ,France ,1981
Uses
Different sources of media describe the Uses of 26750-81-2 differently. You can refer to the following data:
1. Alibendol is an antispasmodic,choleretic, and cholekinetic.
2. An amide analog of Eugenol, and is used therapeutically as an antispasmodic.
Manufacturing Process
36 g of ethyl ester of 2-hydroxy-3-methoxy-5-allyl-benzoic acid [obtained by
the process described by Pearl, et al., J. Amer. Chem. Soc., Vol. 71, 1067-
1068 (1949)] and 61 g of ethanolamine were admixed and left to stand for 1
hour at ambient temperature after which it was heated for 1 hour at 120°C.
The mixture was extracted with chloroform and the organic phases were
washed with half diluted hydrochloric acid, then with water, and the
chloroform evaporated off. The residue, after recrystallization from benzene,
was a 78% yield of 2-hydroxy-3-methoxy-5-allyl-N-(β-hydroxyethyl)-
benzamide having a melting point of 95°C. The product appeared in the form
of colorless crystals which were insoluble in water and soluble in dilute sodium
hydroxide.
Therapeutic Function
Choleretic, Spasmolytic
Check Digit Verification of cas no
The CAS Registry Mumber 26750-81-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,7,5 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 26750-81:
(7*2)+(6*6)+(5*7)+(4*5)+(3*0)+(2*8)+(1*1)=122
122 % 10 = 2
So 26750-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H17NO4/c1-3-4-9-7-10(13(17)14-5-6-15)12(16)11(8-9)18-2/h3,7-8,15-16H,1,4-6H2,2H3,(H,14,17)
26750-81-2Relevant articles and documents
Choleretic drug alibendol preparation method
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Paragraph 0017; 0019-0020; 0022, (2019/06/30)
The invention belongs to the field of drug synthesis, and provides an alibendol preparation method, which comprises: selecting 2-hydroxy-3-methoxybenzaldehyde as a raw material, selecting an efficientoxidative esterification catalyst, carrying out one-step oxidative esterification to obtain methyl 2-hydroxy-3-methoxybenzoate, carrying out a reaction on the methyl 2-hydroxy-3-methoxybenzoate and allyl bromide under the action of an alkali to generate methyl 2-allyloxy-3-methoxybenzoate, carrying out a para Claisen rearrangement reaction on the methyl 2-allyloxy-3-methoxybenzoate at a high temperature to obtain methyl 2-hydroxy-3-methoxy-5-allylbenzoate, and carrying out an aminolysis reaction in ethanolamine to generate alibendol. Compared with the traditional synthetic process, the new process of the present invention has characteristics of simple synthesis steps, convenient post-treatment and good product quality, and is suitable for industrial production.