26759-48-8

Basic information

• Product Name: methyl 3-hydroxy-5,6-dimethoxybenzo[b]thiophene-3-carboxylate
• Synonyms: methyl 3-hydroxy-5,6-dimethoxybenzo[b]thiophene-3-carboxylate;3-Hydroxy-5,6-dimethoxybenzo[b]thiophene-2-carboxylic acid methyl ester
• CAS NO: 26759-48-8
• Molecular Formula: C₁₂H₁₂O₅S
• Molecular Weight: 268.28568
• EINECS: 247-968-2
• Mol File: 26759-48-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 397.9°Cat760mmHg
• Flash Point: 194.5°C
• Appearance: /
• Density: 1.358g/cm³
• Vapor Pressure: 4.78E-07mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: methyl 3-hydroxy-5,6-dimethoxybenzo[b]thiophene-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-hydroxy-5,6-dimethoxybenzo[b]thiophene-3-carboxylate(26759-48-8)
• EPA Substance Registry System: methyl 3-hydroxy-5,6-dimethoxybenzo[b]thiophene-3-carboxylate(26759-48-8)

Safety Data

• Hazardous Substances Data: 26759-48-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H14O5S/c1-15-8-4-7-10(5-9(8)16-2)18-6-12(7,14)11(13)17-3/h4-5,14H,6H2,1-3H3

Upstream product

• 26791-94-6 2-carboxymethylsulfanyl-4,5-dimethoxy-benzoic acid 
• 26759-47-7 methyl 2-(carbomethoxymethylthio)-4,5-dimethoxy-benzoate 

Downstream Products

• 809235-74-3 3-(3-bromo-benzyloxy)-5,6-dimethoxy-benzo[b]thiophene-2-carboxylic acid methyl ester 
• 809235-72-1 5,6-dimethoxy-3-phenethyloxy-benzo[b]thiophene-2-carboxylic acid 
• 809235-75-4 3-(3-bromo-benzyloxy)-5,6-dimethoxy-benzo[b]thiophene-2-carboxylic acid 
• 26759-49-9 methyl 3,5,6-trimethoxybenzo[b]thiophene-2-carboxylate 
• 809235-71-0 5,6-dimethoxy-3-phenethyloxy-benzo[b]thiophene-2-carboxylic acid methyl ester 

Relevant articles and documents

CYCLOALKYL AND HETEROCYCLOALKYL SUBSTITUTED BENZOTHIOPHENES AS THERAPEUTIC AGENTS

The present invention provides benzo[b]thiophenes of Formula (I) wherein R1, R2, R3, and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as age

PHARMACEUTICAL COMPOUNDS

Compounds of the formula: STR1 in which each R 1 is hydrogen, C 1-4 alkyl, C 1-4 alkoxy, halogen or nitro, and n is 0, 1, 2 or 3, R 2 is hydrogen, C 1-4 alkyl or C 2-4 alkenyl, R. sup.3 and R. sup.4 are each hydrogen, C 1-4 alkyl, optionally substituted phenyl or C. sub.6-9 cycloalkyl optionally substituted by 1 to 4 C 1-4 alkyl groups, R 5 is optionally substituted phenyl, tetrahydronaphthyl, phthalimido, saccharinyl, glutaramido, C 6-10 cycloalkyl optionally substituted with 1 to 4 C. sub.1-4 alkyl groups or a phenyl group, or C. sub.4-9 heterosubstituted cycloalkyl optionally substituted with 1 to 4 alkyl groups, x is 1, 2 or 3, y is 0 or 1 and z is 0, 1, 2 or 3; and salts thereof.The compounds are indicated for use in the treatment of disorders of the central nervous system.

3-Alkoxy-thianapthene-2-carboxamides

The 3-alkoxy-thianaphthene-2-carboxamides of this invention are effective for the treatment of mammals afflicted with emesis. When administered to dogs in dosages of 250 μg/kg, compounds of this invention give 100% protection against vomiting normally induced by subcutaneous administration of apomorphine. The compounds of this invention also favorably modify behavior disturbances in mammals.