2676-99-5Relevant academic research and scientific papers
Catalytic enantioselective addition of diethylzinc to trifluoromethyl ketones
Yearick, Kimberly,Wolf, Christian
supporting information; experimental part, p. 3915 - 3918 (2009/05/31)
(Figure Presented) A procedure for nucleophilic addition of diethylzinc to trifluoramethyl ketones was developed. The TMEDA-catalyzed method converts aromatic substrates to the corresponding 2-aryl-1,1,1-trifluorobutan-2-ols in up to 99% yield, and it is also applicable to less reactive aliphatic ketones if stoichiometric ligand amounts are employed. The first asymmetric variant producing tertiary alcohols with up to 61% ee when TBOX is used as catalyst is described.
