267647-77-8Relevant articles and documents
Novel guanidine-Based inhibitors of inosine monophosphate dehydrogenase
Iwanowicz, Edwin J.,Watterson, Scott H.,Liu, Chunjian,Gu, Henry H.,Mitt, Toomas,Leftheris, Katerina,Barrish, Joel C.,Fleener, Catherine A.,Rouleau, Katherine,Sherbina,Hollenbaugh, Diane L.
, p. 2931 - 2934 (2007/10/03)
A series of novel guanidine-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. IMPDH catalyzes the rate determining step in guanine nucleotide biosynthesis and is a target for anticancer, immunosuppressive and antiviral therapy. The synthesis and the structure-activity relationships (SARs), derived from in vitro studies, for this new series of inhibitors is given.