267647-89-2Relevant academic research and scientific papers
MODULATORS FOR AMYLOID BETA
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Page/Page column 11, (2009/07/25)
The invention relates to compounds of formula wherein R1, R2, R3, R4, X and Y are as defined herein and to pharmaceutically active acid addition salts thereof. The compounds can be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.
A survey of cyclic replacements for the central diamide moiety of inhibitors of inosine monophosphate dehydrogenase
Dhar,Liu, Chunjian,Pitts, William J.,Guo, Junquing,Watterson, Scott H.,Gu, Henry,Fleener, Catherine A.,Rouleau, Katherine,Sherbina,Barrish, Joel C.,Hollenbaugh, Diane,Iwanowicz, Edwin J.
, p. 3125 - 3128 (2007/10/03)
A series of heterocyclic replacements for the central diamide moiety of 1, a potent small molecule inhibitor of inosine monophosphate dehydrogenase (IMPDH) were explored. The synthesis and the structure-activity relationships (SARs), derived from in vitro
Compounds derived from an amine nucleus that are inhibitors of IMPDH enzyme
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, (2008/06/13)
The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH mediated diseases, such as transplant rejection and autoimmune diseases.
