267661-42-7

Basic information

• Product Name: Acetic acid (3S,6S,8aS)-3-(tert-butyl-diphenyl-silanyloxymethyl)-6-methyl-5-oxo-octahydro-indolizin-6-yl ester
• CAS NO: 267661-42-7
• Molecular Weight: 479.692
• Mol File: 267661-42-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid (3S,6S,8aS)-3-(tert-butyl-diphenyl-silanyloxymethyl)-6-methyl-5-oxo-octahydro-indolizin-6-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid (3S,6S,8aS)-3-(tert-butyl-diphenyl-silanyloxymethyl)-6-methyl-5-oxo-octahydro-indolizin-6-yl ester(267661-42-7)
• EPA Substance Registry System: Acetic acid (3S,6S,8aS)-3-(tert-butyl-diphenyl-silanyloxymethyl)-6-methyl-5-oxo-octahydro-indolizin-6-yl ester(267661-42-7)

Safety Data

• Hazardous Substances Data: 267661-42-7(Hazardous Substances Data)

Upstream product

• 267661-17-6 (3S,6S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-6-hydroxy-8-(4-methoxy-benzyloxy)-6-methyl-hexahydro-indolizin-5-one 
• 267661-39-2 (3S,6S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-8-(4-methoxy-benzyloxy)-6-methyl-hexahydro-indolizin-5-one 
• 267661-10-9 (3S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-8-(4-methoxy-benzyloxy)-hexahydro-indolizin-5-one 
• 267661-40-5 (3S,6S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-6,8-dihydroxy-6-methyl-hexahydro-indolizin-5-one 
• 181705-84-0 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-oxo-tetrahydro-furan-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 181705-70-4 (5S,2'S,5'S)-5-[1'-(tert-butoxycarbonyl)-5'-(tert-butyldiphenylsilyloxymethyl)pyrrolidin-2'-yl]-2(5H)-furanone 
• 181705-72-6 (3S,8S,9R)-3-(tert-butyldiphenylsilanyloxymethyl)-8-hydroxyhexahydroindolizin-5-one 
• 181705-71-5 (5S,2'S,5'S)-5-[5'-(tert-butyldiphenylsilyloxymethyl)pyrrolidin-2'yl]-tetrahydrofuran-2-one 
• 108-24-7 acetic anhydride 
• 267661-41-6 (3S,6S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-6-hydroxy-6-methyl-hexahydro-indolizin-5-one 

Downstream Products

• 267661-45-0 [1-Amino-1-(4-{[((3S,6S,8aS)-6-hydroxy-6-methyl-5-oxo-octahydro-indolizine-3-carbonyl)-amino]-methyl}-phenyl)-meth-(Z)-ylidene]-carbamic acid benzyl ester 

Relevant articles and documents

Exploring the chiral space within the active site of α-thrombin with a constrained mimic of D-Phe-Pro-Arg - Design, synthesis, inhibitory activity, and X-ray structure of an enzyme-inhibitor complex

An indolizidinone motif with strategically placed substitutents was designed and synthesized as a constrained mimic of D-Phe-Pho-Arg. Low nanomolar inhibition of α-thrombin validates the design elements in this inhibitor which also exhibits a 20-fold selectivity for thrombin versus trypsin. An X-ray crystal structure of the inhibitor with α-thrombin shows the expected interactions with key amino acids within the active site and some notable changes in positions. (C) Elsevier Science Ltd. All rights reserved.