267666-12-6

Basic information

• Product Name: 1-(2-nitro-benzenesulfonyl)-piperidin-3-one
• Synonyms: 1-(2-nitro-benzenesulfonyl)-piperidin-3-one
• CAS NO: 267666-12-6
• Molecular Weight: 284.293
• Mol File: 267666-12-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-nitro-benzenesulfonyl)-piperidin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-nitro-benzenesulfonyl)-piperidin-3-one(267666-12-6)
• EPA Substance Registry System: 1-(2-nitro-benzenesulfonyl)-piperidin-3-one(267666-12-6)

Safety Data

• Hazardous Substances Data: 267666-12-6(Hazardous Substances Data)

Upstream product

• 64051-79-2 piperidin-3-ol hydrochloride 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 

Downstream Products

• 1026716-28-8 3,3-dimethoxy-1-(2-nitro-benzenesulfonyl)-piperidine 
• 267666-35-3 9-benzenesulfonyl-7-methoxy-2-(2-nitrobenzenesulfonyl)-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol 
• 267666-41-1 9-benzenesulfonyl-6,7-dimethoxy-2-(2-nitrobenzenesulfonyl)-2,3,4,9-tetrahydro-1H-β-carboline 

Relevant articles and documents

Lewis Acid-Directed Cyclocondensation of Piperidone Enol Ethers with 2-Methoxy-4-(N-phenylsulfonyl)-1,4-benzoquinoneimine: A New Regioselective Synthesis of Oxygenated Carbolines

Lewis acid-directed cyclocondensations of piperidone enol ethers with 2-methoxy-4-(N-phenylsulfonyl)-1,4-henzoquinoneimine are reported. Benzofurans are obtained with BF3·OEt2 as a promoter, whereas use of excess amounts of TiCl4:Ti(OiPr)4 leads to tetrahydrocarbolines. The latter reactions provide expedient routes to oxygen-substituted tetrahydrocarbolines and carbolines. As applications of this new methodology, the preparations of 1-[3-(dimethylamino)propyl]amino-7-methoxy- and 1-[3-(dimethylamino)propyl]amino-7,8-dimethoxy-5H-pyrido[4,3-b]indoles are described.