26771-96-0 Usage
Main Properties
1. Potent and stable metabolite of prostacyclin
2. Derived from the metabolism of arachidonic acid
3. Produced in response to inflammation and oxidative stress
4. Reliable marker for oxidative stress in humans
5. Associated with diseases such as diabetes, hypertension, and cardiovascular disease
6. Plays a role in the pathogenesis of atherosclerosis
7. Potential biomarker for assessing the risk of cardiovascular events
8. Investigated for potential therapeutic use in oxidative stress-related diseases
Specific Content
1. Chemical compound: 8-EPI PGF1ALPHA
2. Function: Vasodilator and inhibitor of platelet aggregation
3. Source: Eicosanoid derived from arachidonic acid metabolism
4. Use as a marker: Reliable for measuring oxidative stress in humans
5. Disease associations: Linked to diabetes, hypertension, and cardiovascular disease
6. Role in atherosclerosis: Implicated in the development of this condition
7. Biomarker for cardiovascular risk: Used to assess the likelihood of cardiovascular events
8. Therapeutic potential: Being investigated for treating diseases related to oxidative stress
Check Digit Verification of cas no
The CAS Registry Mumber 26771-96-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,7,7 and 1 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 26771-96:
(7*2)+(6*6)+(5*7)+(4*7)+(3*1)+(2*9)+(1*6)=140
140 % 10 = 0
So 26771-96-0 is a valid CAS Registry Number.
26771-96-0Relevant articles and documents
Total synthesis of isoprostanes via the two-component coupling process
Rodríguez, Ana R.,Spur, Bernd W.
, p. 4575 - 4579 (2007/10/03)
A short total synthesis of isoprostanes has been achieved using a two-component coupling process combined with a diastereoselective protonation under reagent control. The F1-isoprostanes were easily obtained by stereoselective reduction of the C-9 keto group.
Stereocontrolled Synthesis of Prostaglandins from Cyclopentadiene Monoepoxide
Marino, Joseph P.,Pradilla, Roberto Fernandez de la,Laborde, Edgardo
, p. 5279 - 5280 (2007/10/02)
Two complementary syntheses of prostaglandins from the same key intermediate 3, available in four steps from cyclopentadiene monoepoxide, are described.In one approach, a saturated α-chain is introduced via a 1,4-addition of an appropriately functionalized cyanocuprate reagent onto silyl enol ether 3.The resulting prostanoid compound was converted into the bronchodilator 1-decarboxy-1-hydroxymethyl PGE1, PGE1, and PGF1α.The second approach involves the transformation of silyl enol ether 3 into the known prostanoid precursor 11 via selective addition of carbethoxycarbene and subsequent fluoride-induced ring opening of the resulting (silyloxy)cyclopropane carboxylate ester.
Total synthesis of prostaglandins. Synthesis of the pure dl-E1, -F1-alpha-F1-beta, -A1, and -B1 hormones.
Corey,Andersen,Carlson,Paust,Vedejs,Vlattas,Winter
, p. 3245 - 3247 (2007/10/12)
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