26787-75-7

Basic information

• Product Name: (R)-(N-benzyloxycarbonyl)-p-hydroxyphenylglycine
• Synonyms: (R)-(N-benzyloxycarbonyl)-p-hydroxyphenylglycine;N-Carbobenzoxy-4-hydroxy-D-2-phenylglycine;N-Carbobenzoxy-4-hydroxy-D-2-phenylglycine;(2R)-2-(4-hydroxyphenyl)-2-(phenylmethoxycarbonylamino)acetic acid;N-Cbz-R-4-Hydroxyphenylglycine
• CAS NO: 26787-75-7
• Molecular Formula: C₁₆H₁₅NO₅
• Molecular Weight: 301.294
• Mol File: 26787-75-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 552.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.356±0.06 g/cm3(Predicted)
• Solubility: soluble in Methanol
• PKA: 3.69±0.10(Predicted)
• CAS DataBase Reference: (R)-(N-benzyloxycarbonyl)-p-hydroxyphenylglycine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(N-benzyloxycarbonyl)-p-hydroxyphenylglycine(26787-75-7)
• EPA Substance Registry System: (R)-(N-benzyloxycarbonyl)-p-hydroxyphenylglycine(26787-75-7)

Safety Data

• Hazardous Substances Data: 26787-75-7(Hazardous Substances Data)

Usage

General Description

"(R)-(N-benzyloxycarbonyl)-p-hydroxyphenylglycine" is a chemical compound that belongs to the category of amino acids. It is a specific derivative of p-hydroxyphenylglycine, which is an important building block for the synthesis of pharmaceuticals and agrochemicals. The presence of the (R)- configuration in this compound indicates that it is the enantiomer with the absolute configuration that correlates to the standard sequence of the stereochemical descriptors. (R)-(N-benzyloxycarbonyl)-p-hydroxyphenylglycine is often used in the synthesis of various pharmaceuticals and research chemicals due to its unique structure and properties. However, it should be handled and used with caution, as it may have hazardous effects if not properly managed.

Upstream product

• 22818-40-2 D-4-hydroxyphenylglycine 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 123004-75-1 D-N-(benzyloxycarbonyl)-2-<4--3-(tert-butoxycarbonyl)propoxy>phenyl>glycine 
• 136057-28-8 (R)-4-{3-[4-((R)-2-[(R)-2-Benzyloxycarbonylamino-2-(4-hydroxy-phenyl)-acetylamino]-2-{[(S)-tert-butoxycarbonyl-(4-tert-butoxy-phenyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-phenyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 123004-76-2 (R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester 
• 123004-77-3 (R)-4-[4-((R)-Amino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester; hydrochloride 
• 110269-45-9 di-tert-butyl N-(tert-butoxycarbonyl)nocardicin A 
• 60134-71-6 (-)-nocardicin B 

Relevant articles and documents

Semi-Rigid Nitroxide Spin Label for Long-Range EPR Distance Measurements of Lipid Bilayer Embedded β-Peptides

β-Peptides are an interesting new class of transmembrane model peptides based on their conformationally stable and well-defined secondary structures. Herein, we present the synthesis of the paramagnetic β-amino acid β3-hTOPP (4-(3,3,5,5-tetramethyl-2,6-dioxo-4-oxylpiperazin-1-yl)-d-β3-homophenylglycine) that enables investigations of β-peptides by EPR spectroscopy. This amino acid adds to the, to date, sparse number of β-peptide spin labels. Its performance was evaluated by investigating the helical turn of a 314-helical transmembrane model β-peptide. Nanometer distances between two incorporated β3-hTOPP labels in different environments were measured by using pulsed electron/electron double resonance (PELDOR/DEER) spectroscopy. Due to the semi-rigid conformational design, the label delivers reliable distances and sharp (one-peak) distance distributions even in the lipid bilayer. The results indicate that the investigated β-peptide folds into a 3.2514 helix and maintains this conformation in the lipid bilayer.

BENZOTHIAZEPINE AND BENZOTHIADIAZEPINE DERIVATIVES WITH ILEAL BILE ACID TRANSPORT (IBAT) INHIBITORY ACTIVITY FOR THE TREATMENT HYPERLIPIDAEMIA

The present invention relates to compounds of formula (I) wherein Rv, R1, R2, Rx, Ry, M, Rz, v, R3, R4, R5 and R6 are as defined within; pharmace

Asymmetric synthesis of α-amino acids via cinchona alkaloid-catalyzed kinetic resolution of urethane-protected α-amino acid N-carboxyanhydrides

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