267875-55-8

Basic information

• Product Name: 1H-Indazole-5-carbonitrile, 3-methyl-
• Synonyms: 1H-Indazole-5-carbonitrile, 3-methyl-;3-Methyl-1H-indazole-5-carbonitrile;3-methyl-2H-indazole-5-carbonitrile
• CAS NO: 267875-55-8
• Molecular Formula: C9H7N3
• Molecular Weight: 157.17
• Mol File: 267875-55-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 372.9±22.0 °C(Predicted)
• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.58±0.40(Predicted)
• CAS DataBase Reference: 1H-Indazole-5-carbonitrile, 3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole-5-carbonitrile, 3-methyl-(267875-55-8)
• EPA Substance Registry System: 1H-Indazole-5-carbonitrile, 3-methyl-(267875-55-8)

Safety Data

• Hazardous Substances Data: 267875-55-8(Hazardous Substances Data)

Usage

General Description

"1H-Indazole-5-carbonitrile, 3-methyl-" is a chemical compound from the indazole family, which consists of organic compounds containing a benzene ring fused to a pyrazole ring. The term "1H" depicts the compound's hydrogen-1 isotope, indicating there is one hydrogen atom present in its molecular structure. The "5-carbonitrile" denotes that a carbonitrile group is located at the fifth position on the indazole ring structure. The "3-methyl" indicates the presence of a methyl group at the third position of the ring. However, additional details such as its physical and chemical properties, uses, and safety measures, might differ and needed to be carefully researched before handling the chemical.

Upstream product

• 552331-16-5 5-bromo-3-methyl-1H-indazole 
• 557-21-1 zinc(II) cyanide 
• 552331-49-4 tert-butyl 5-bromo-3-methyl-1H-indazole-1-carboxylate 
• 557-21-1 dicyanozinc 
• 170230-87-2 4'-amino-3'-ethylbenzonitrile 

Downstream Products

• 1015068-76-4 3-methyl-1H-indazole-5-carboxylic acid methyl ester 
• 1015070-98-0 C₁₁H₁₂N₂O₂ 

Relevant articles and documents

EGFR INHIBITOR, AND PREPARATION AND APPLICATION THEREOF

A 4-substituted-2-(N-(5-substituted allyl amide)phenyl)amino)pyrimidine derivative as represented by formula (I), and a preparation and application thereof as an EGFR inhibitor. The compound has activity of inhibiting the L858R EGFR mutant, the T790M EGFR mutant and the exon 19 deletion activating mutant, may be used to treat diseases mediated alone or in part by EGFR mutant activity, and has a wide application in drugs preventing and treating cancers, particularly non-small cell lung cancer.

Thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein b is NY or O; c is CY2or N; d is CY3or N; e is CY4or N; f is CY5or N; g is CY6or N; Y4, Y5, and Y6are independently hydrogen, C1-4alkyl, or halogen; Y1and Y2are independently hydrogen, C1-4alkyl, C3-7cycloalkyl, halogen, NH2, OH or C1-4alkoxy, and Y3is hydrogen, C1-4alkyl, C3-7cycloalkyl, halogen, —CN, NH2, OH or C1-4alkoxy; A is and W, W1, R1, R3, R4, R5, X and Z are defined in the specification.