26806-47-3Relevant academic research and scientific papers
PYRIDAZINONES AND FURAN-CONTAINING COMPOUNDS
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Page/Page column 94-95, (2008/12/07)
The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing these compounds, methods of syntheses, and a method of treatment of a proliferative disease in a subject by administration of a therapeutically effective amount of a compound of formulae (I) or (II). Both classes of compounds were identified through screening of a collection of small molecule libraries.
Confirmation and prevention of halogen exchange: practical and highly efficient one-pot synthesis of dibromo- and dichloropyridazinones
Zhang, Ji,Morton, Howard E.,Ji, Jianguo
, p. 8733 - 8735 (2007/10/03)
Commercially available anilines were converted by a two step, one-pot process to the corresponding pyridazinones in good to excellent yields. During the process research, a significant halogen exchange was confirmed and prevented which allowed the process to be scaled to multikilogram quantities.
Preparation of 1-aryl-4,5-dihalo-pyridazone-6
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, (2008/06/13)
Disclosed is single phase multi-stage process for preparation of 1-aryl-4,5-dihalo-pyridazones-6 involving the diazotization of an amino aryl compound, e.g. aniline, followed by reduction with sulfurous acid to obtain the corresponding aryl hydrazine which is then reacted at elevated temperatures with a mucohalic acid to obtain the 1-aryl-4,5-dihalo-pyridazone-6.
