268206-05-9Relevant academic research and scientific papers
Selective carbonylation routes to thiocarbamates. An alternative to phosgene
Jones, William D.,Reynolds, Kelly A.,Sperry, Caroline K.,Lachicotte, Rene J.,Godleski, Stephen A.,Valente, Ronald R.
, p. 1661 - 1669 (2000)
A new route for the synthesis of thiocarbamates using a transition metal complex and CO as a replacement for phosgene has been discovered. The complex (PPh3)2PdCl2 reacts with N-benzylmethylamine, 4-chlorobenzenethiol, and CO to selectively generate a thiocarbamate. Kinetic studies and the isolation of several intermediates in this reaction allow for the proposal of a mechanistic scheme.
