268539-14-6

Basic information

• Product Name: 1-O-<2-N-(N-benzyloxycarbonyl glycylglycyl)ethyl>-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside
• Synonyms: 1-O-<2-N-(N-benzyloxycarbonyl glycylglycyl)ethyl>-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside
• CAS NO: 268539-14-6
• Molecular Weight: 639.613
• Mol File: 268539-14-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-O-<2-N-(N-benzyloxycarbonyl glycylglycyl)ethyl>-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: 1-O-<2-N-(N-benzyloxycarbonyl glycylglycyl)ethyl>-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside(268539-14-6)
• EPA Substance Registry System: 1-O-<2-N-(N-benzyloxycarbonyl glycylglycyl)ethyl>-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside(268539-14-6)

Safety Data

• Hazardous Substances Data: 268539-14-6(Hazardous Substances Data)

Upstream product

• 2566-19-0 CbzGlyGly 
• 153324-49-3 (2R,3R,4S,5S,6S)-2-(acetoxymethyl)-6-(2-aminoethoxy)tetrahydro-2-H-pyran-3,4,5-triyl triacetate 
• 83-87-4 D-Mannose pentaacetate 
• 3947-62-4 2,3,4,6-tetra-O-acetyl-D-mannopyranose 
• 121238-27-5 2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl trichloroimidate 
• 140428-83-7 2-azidoethyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 

Downstream Products

• 268539-16-8 5-azidomethyl-N,N'-bis<2-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-N-ethylglycylglycyl>benzene-1,3-dicarboxamide 
• 268539-15-7 1-O-<2-(N-benzylamidoglycylglycyl)ethyl>-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 

Relevant articles and documents

A comparison of biological and calorimetric analyses of multivalent glycodendrimer ligands for concanavalin A

The cluster glycoside effect - the observation that multivalent glycosides bind to their polyvalent protein receptors with apparent affinities greater than those that can be rationalized solely on the basis of valency - is by now a well established phenomenon. As part of a continuing effort to provide a molecular basis for the cluster glycoside effect, we report here the synthesis of two series of mannosylated dendritic ligands and their performance in a range of competitive and non-competitive binding assays, including hemeagglutination inhibition (HIA), enzyme-linked lectin assays (ELLA) and isothermal titration microcalorimetry (ITC). The first series of ligands contained a semi-rigid glycylglycine spacer and showed no significant performance enhancement in any binding studies. The second series of ligands contained a flexible tetraethylene glycol spacer; these ligands showed marked enhancements at tetravalent and hexavalent levels in both HIA (IC50=3 and4 and 1.5x106 M-1, respectively) studies. In all cases, the thermodynamic parameters of association are consistent with non-specific aggregation rather than enhanced lectin-ligand affinity. This conclusion is reinforced by the lack of enhancements in ligand activity observed in ELLA studies. Copyright (C) 2000 Elsevier Science Ltd.