268556-62-3

Basic information

• Product Name: (2R)-2-aMino-3,3-diMethyl-N-(phenylMethyl)-ButanaMide
• Synonyms: (2R)-2-aMino-3,3-diMethyl-N-(phenylMethyl)-ButanaMide;(2R)-2-Amino-3,3-dimethyl-N-(phenylmethyl)butanamide,99%e.e.;(2R)-2-Amino-3,3-dimethyl-N-(phenylmethyl)butanamide, 98%, (99% ee)
• CAS NO: 268556-62-3
• Molecular Formula: C₁₃H₂₀N₂O
• Molecular Weight: 220.3107
• Mol File: 268556-62-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 394.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.025±0.06 g/cm3(Predicted)
• PKA: 15.48±0.46(Predicted)
• CAS DataBase Reference: (2R)-2-aMino-3,3-diMethyl-N-(phenylMethyl)-ButanaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-aMino-3,3-diMethyl-N-(phenylMethyl)-ButanaMide(268556-62-3)
• EPA Substance Registry System: (2R)-2-aMino-3,3-diMethyl-N-(phenylMethyl)-ButanaMide(268556-62-3)

Safety Data

• Hazardous Substances Data: 268556-62-3(Hazardous Substances Data)

Usage

General Description

"(2R)-2-aMino-3,3-diMethyl-N-(phenylMethyl)-ButanaMide" is a chemical compound categorized as an amide. It is a chiral compound with the (2R) configuration, indicating that it has a specific arrangement of atoms around a carbon center. The molecule consists of an amino group, two methyl groups, and a phenylmethyl group attached to a four-carbon aliphatic chain. (2R)-2-aMino-3,3-diMethyl-N-(phenylMethyl)-ButanaMide may have potential applications in the field of medicinal chemistry or organic synthesis, as it possesses unique structural and functional properties that could be explored for various purposes. Additionally, further research and studies may be needed to fully understand the characteristics and potential uses of this chemical.

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Relevant articles and documents

Primary amino acid derivatives: Compounds with anticonvulsant and neuropathic pain protection activities

Pharmacological management remains the primary method to treat epilepsy and neuropathic pain. We have advanced a novel class of anticonvulsants termed functionalized amino acids (FAAs). In this study, we examine FAA derivatives from which the terminal acetyl moiety was removed and termed these compounds primary amino acid derivatives (PAADs). Twenty-seven PAADs were prepared; the central C(2) R-substituent was varied, including C(2) stereochemistry, and the compounds were tested in rodent models of seizures and neuropathic pain. C(2)-Hydrocarbon N-benzylamide PAADs were potent anticonvulsants and excellent anticonvulsant activity (mice, ip; rat, po) was observed for C(2) R-substituted PAADs in which the R group was ethyl, isopropyl, or tert-butyl, and the C(2) stereochemistry conformed to the d-amino acid configuration ((R)-stereoisomer). These values surpassed the activities of several clinical antiepileptic drugs. The C(2) (R)-ethyl and C(2) (R)-isopropyl PAADs also displayed excellent activities in the mouse (ip) formalin neuropathic pain model. Significantly, unlike the FAA structure-activity relationship, PAAD anticonvulsant activity increased upon substitution of a methylene unit for a heteroatom in the R-substituent that was one atom removed from the C(2) site, suggesting that these PAADs function by a different pathway than FAAs.

Enantioselective catalytic addition of HCN to ketoimines. Catalytic synthesis of quaternary amino acids.

[formula: see text] Highly enantioselective addition of HCN to ketoimines has been achieved for the first time using readily accessible and recyclable Schiff base catalysts. Essentially quantitative isolated yield and enantioselectivity of up to 95% ee wa