268565-29-3Relevant articles and documents
Synthesis and antifungal activity of rhodopeptin analogues. 1. Modification of the east and south amino acid moieties
Kawato, Haruko C.,Nakayama, Kiyoshi,Inagaki, Hiroaki,Nakajima, Ryohei,Kitamura, Akihiro,Someya, Kazuhiko,Ohta, Toshiharu
, p. 973 - 976 (2007/10/03)
(equation presented) East Amino Acid n=8, 10 South Amino Acid Synthetic Rhodopeptin Analogs Structure - activity relationships of the east and south amino acid modified analogues of rhodopeptins, novel antifungal cyclic tetrapeptides isolated from Rhodococcus species Mer-N1033, have been investigated. It was observed that a basic amino acid moiety (lysine or ornithine) as the east amino acid and a hydrophobic and bulky neutral amino acid (i.e., γ-methylleucine) as the south amino acid were indispensable structure motifs for antifungal activity of rhodopeptin analogues.