268565-29-3Relevant academic research and scientific papers
Synthesis and antifungal activity of rhodopeptin analogues. 1. Modification of the east and south amino acid moieties
Kawato, Haruko C.,Nakayama, Kiyoshi,Inagaki, Hiroaki,Nakajima, Ryohei,Kitamura, Akihiro,Someya, Kazuhiko,Ohta, Toshiharu
, p. 973 - 976 (2007/10/03)
(equation presented) East Amino Acid n=8, 10 South Amino Acid Synthetic Rhodopeptin Analogs Structure - activity relationships of the east and south amino acid modified analogues of rhodopeptins, novel antifungal cyclic tetrapeptides isolated from Rhodococcus species Mer-N1033, have been investigated. It was observed that a basic amino acid moiety (lysine or ornithine) as the east amino acid and a hydrophobic and bulky neutral amino acid (i.e., γ-methylleucine) as the south amino acid were indispensable structure motifs for antifungal activity of rhodopeptin analogues.
