268734-41-4 Usage
Derivative of benzisoxazole
Yes
It is derived from the aromatic ring system benzisoxazole, which contains an oxygen and a nitrogen atom.
Organofluorine compound
Yes
The presence of two fluorine atoms on the benzene ring classifies this compound as an organofluorine compound.
Unique properties and reactivity
Potential
As an organofluorine compound, it may possess unique properties and reactivity compared to other similar compounds without fluorine atoms.
Potential applications
Pharmaceuticals, agrochemicals, and materials science
Due to its structural features and potential biological activities, this compound may have applications in various fields, including pharmaceuticals, agrochemicals, and materials science.
Research status
Ongoing
More research is needed to fully understand the properties and potential uses of 1,2-Benzisoxazol-3-amine,4,6-difluoro-(9CI).
Chemical structure
Aromatic ring system with fluorine atoms
The compound features an aromatic ring system with two fluorine atoms attached, which may contribute to its unique properties and reactivity.
Biological activities
Potential
The compound may exhibit biological activities due to its structural features, but further research is required to confirm and explore these activities.
CAS Registry Number
9CI
The compound is registered under the CAS Registry Number 9CI, which is a unique identifier for chemical substances.
Check Digit Verification of cas no
The CAS Registry Mumber 268734-41-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,8,7,3 and 4 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 268734-41:
(8*2)+(7*6)+(6*8)+(5*7)+(4*3)+(3*4)+(2*4)+(1*1)=174
174 % 10 = 4
So 268734-41-4 is a valid CAS Registry Number.
268734-41-4Relevant articles and documents
Studies on the synthetic compatibility of aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles
Lepore, Salvatore D.,Wiley, Michael R.
, p. 2924 - 2932 (2007/10/03)
Further exploration of the scope of our solid-phase method for the synthesis of 3-aminobenzisoxazoles (using the Kaiser oxime resin 1) is described. The effects of base, leaving group, and solvent on the nucleophilic aromatic substitution based resin-loading reaction are discussed. Representative aryloxime intermediates were subjected to a variety of acidic conditions commonly used in protecting group removal to establish the acid stability profile of this linker. Regioselectivity was evaluated with various di- and trifluorobenzonitriles, which gave single benzisoxazole products after loading and cyclorelease reactions. Substituent effects observed in the course of the acid stability and regioselectivity studies suggest that the nitrile plays a critical role in the oxime hydrolysis mechanism. Finally, to establish the compatibility of the aryloxime linker with a variety of useful on-resin synthetic transformations, functionalized substrates were loaded onto resin 1, and carbon-nitrogen, carbon-oxygen, and carbon-carbon bond-forming reactions were successfully executed.
