268736-72-7Relevant academic research and scientific papers
Total Synthesis of Apoptolidin: Construction of Enantiomerically Pure Fragments
Nicolaou,Fylaktakidou, Konstantina C.,Monenschein, Holger,Li, Yiwei,Weyershausen, Bernd,Mitchell, Helen J.,Wei, Heng-Xu,Guntupalli, Prasuna,Hepworth, David,Sugita, Kazuyuki
, p. 15433 - 15442 (2007/10/03)
A general strategy for the total synthesis of the antitumor agent apoptolidin (1) is proposed, and the chemical synthesis of the defined key building blocks (4, 5, 6, 8, and 9) in their enantiomerically pure forms is described. The projected total synthes
Total synthesis of apoptolidin: Part 1. Retrosynthetic analysis and construction of building blocks
Nicolaou,Li, Yiwei,Fylaktakidou, Konstantina C.,Mitchell, Helen J.,Wei, Heng-Xu,Weyershausen, Bernd
, p. 3849 - 3854 (2007/10/03)
No less than 30 stereogenic elements, a highly unsaturated 20-membered macrocyclic system, four carbohydrate units, and unique biological activity, make the natural occurring apoptolidin (1) a challenging synthetic target. The retrosynthetic analysis reve
Synthesis of the macrocyclic core of apoptolidin
Nicolaou,Li, Yiwei,Weyershausen, Bernd,Wei, Heng-Xu
, p. 307 - 308 (2007/10/03)
The convergent synthesis of the apoptolidin macrocyclic core is described.
