268747-19-9

Upstream product

• 114715-76-3 (3-diazo-1-(S)-(1-methylpropyl)-2-oxopropyl)carbamic acid benzyl ester 
• 41446-04-2 Z-Ile-O-COOiBu 
• 3160-59-6 N-Cbz-L-Isoleucine 

Downstream Products

• 1027083-91-5 [(1S,2S)-1-(5,6-Dihydro-pyrazin-2-yl)-2-methyl-butyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of amino acid-derived imidazoles from enantiopure N-protected α-amino glyoxals

A range of novel imidazoles, including three histidine derivatives, with chiral side chains derived from amino acids and dipeptides have been synthesised from N-Cbz-protected α-amino glyoxals. (C) 2000 Elsevier Science Ltd.

Enantiopure N-protected α-amino glyoxals 1. Synthesis from α-amino acids and some condensation reactions with amines

A series of N-protected α-ammo diazoketones has been prepared from L-amino acids and dipeptides and used as precursors in the synthesis of novel N-protected α-amino glyoxals via oxidation with distilled dimethyldioxirane (DMD) in acetone. The glyoxals have been converted, without purification, into enantiopure imines, pyrazines, quinoxalines, and pyrido[2,3-b]pyrazines via condensation with the appropriate amine or diamine. The molecular structure of the pyrido[2,3-b]pyrazine derived from N-Cbz-L-phenylalanine has been determined by X-ray analysis.