26893-14-1

Basic information

• Product Name: 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• CAS NO: 26893-14-1
• Molecular Formula: C₁₄H₁₄ClNO₄
• Molecular Weight: 295.72
• Mol File: 26893-14-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 390.2±37.0 °C(Predicted)
• Appearance: /
• Density: 1.279±0.06 g/cm3(Predicted)
• PKA: 2.18±0.41(Predicted)
• CAS DataBase Reference: 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(26893-14-1)
• EPA Substance Registry System: 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(26893-14-1)

Safety Data

• Hazardous Substances Data: 26893-14-1(Hazardous Substances Data)

Upstream product

• 26717-39-5 [[(3,4-Dimethoxyphenyl)amino]methylene]malonic acid,diethyl ester 
• 13436-14-1 ethyl 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylate 
• 6315-89-5 3,4-dimethoxyaniline 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 13436-14-1 ethyl 6,7-dimethoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate 

Downstream Products

• 305801-19-8 4-chloro-6,7-dimethoxyquinoline-3-carboxylic acid 
• 214484-25-0 4-[(3-bromophenyl)amino]-6,7-dihydroxy-3-quinolinecarbonitrile 
• 214488-80-9 4-[(3-bromophenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrile 
• 476191-84-1 4-((4-chloro-2-fluorophenyl)amino)-6,7-dimethoxyquinoline-3-carboxamide 
• 1373767-25-9 ethyl 6,7-dimethoxy-4-oxo-2-(3-phenoxyphenyl)-1,4-dihydroquinoline-3-carboxylate 
• 1373767-24-8 ethyl 6,7-dimethoxy-2-(3-methoxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1373767-23-7 ethyl 2-([1,1'-biphenyl]-3-yl)-6,7-dimethoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate 

Relevant articles and documents

Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

Recent literature has claimed that inhibition of the enzyme MTH1 can eradicate cancer. MTH1 is one of the housekeeping enzymes that are responsible for hydrolyzing damaged nucleotides in cells and thus prevent them from being incorporated into DNA. We have developed orthogonal and chemically distinct tool compounds to those published in the literature to allow us to test the hypothesis that inhibition of MTH1 has wide applicability in the treatment of cancer. Here we present the work that led to the discovery of three structurally different series of MTH1 inhibitors with excellent potency, selectivity, and proven target engagement in cells. None of these compounds elicited the reported cellular phenotype, and additional siRNA and CRISPR experiments further support these observations. Critically, the difference between the responses of our highly selective inhibitors and published tool compounds suggests that the effect reported for the latter may be due to off-target cytotoxic effects. As a result, we conclude that the role of MTH1 in carcinogenesis and utility of its inhibition is yet to be established.

Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase

3-Amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modifications at the quinoline 6- and 7-positions.

SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS

This invention provides compounds of formula (1) wherein R1, G1, G2, R4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof, which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.