26893-17-4

Basic information

• Product Name: ETHYL 8-CHLORO[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLATE
• Synonyms: 8-Chloro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylicacid ethyl ester
• CAS NO: 26893-17-4
• Molecular Formula: C₁₃H₁₀ClNO₄
• Molecular Weight: 279.6797
• Mol File: 26893-17-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 392.2 °C at 760 mmHg
• Flash Point: 191 °C
• Appearance: /
• Density: 1.439 g/cm³
• Vapor Pressure: 2.34E-06mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: ETHYL 8-CHLORO[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 8-CHLORO[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLATE(26893-17-4)
• EPA Substance Registry System: ETHYL 8-CHLORO[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLATE(26893-17-4)

Safety Data

• Hazardous Substances Data: 26893-17-4(Hazardous Substances Data)

Usage

General Description

Ethyl 8-chloro[1,3]dioxolo[4,5-g]quinoline-7-carboxylate is a chemical compound with a complex molecular structure. It is a derivative of quinoline, a heterocyclic organic compound. ETHYL 8-CHLORO[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLATE contains an ethyl group, a chlorine atom, and a carboxylate group, which contributes to its potential medicinal and pharmaceutical applications. The presence of the chloro and dioxolo rings in the structure adds to its unique properties and potential biological activities. Overall, this compound has the potential for further research and development in the fields of medicinal chemistry and drug discovery.

InChI:InChI=1/C13H10ClNO4/c1-2-17-13(16)8-5-15-9-4-11-10(18-6-19-11)3-7(9)12(8)14/h3-5H,2,6H2,1H3

Upstream product

• 17394-77-3 diethyl [[3,4-(methylenedioxy)phenylamino]methylene]malonate 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 14205-65-3 ethyl 8-hydroxy-1,3-dioxolo[4,5-g]quinoline-7-carboxylate 
• 32953-23-4 Ethyl α-ethoxycarbonyl-β-N-(5-benzodioxolyl)-N-ethylaminoacrylate 

Downstream Products

• 502172-37-4 8-(4-Butyl-phenylamino)-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid ethyl ester 
• 130373-14-7 8-(4-Butoxy-phenylamino)-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid ethyl ester 
• 130373-12-5 8-m-Tolylamino-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid ethyl ester 
• 131202-36-3 8-(2,3-Dimethyl-phenylamino)-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid ethyl ester 

Relevant articles and documents

Design, Synthesis, and Dual Evaluation of Quinoline and Quinolinium Iodide Salt Derivatives as Potential Anticancer and Antibacterial Agents

A series of novel quinoline and quinolinium iodide derivatives were designed and synthesized to discover potential anticancer and antibacterial agents. With regard to anticancer properties, in vitro cytotoxicities against three human cancer cell lines (A-549, HeLa and SGC-7901) were evaluated. The antibacterial properties against two strains, Escherichia coli (ATCC 29213) and Staphylococcus aureus (ATCC 8739), along with minimum inhibitory concentration (MIC) values were evaluated. The target alkyliodine substituted compounds exhibited significant antitumor and antibacterial activity, of which compound 8-((4-(benzyloxy)phenyl)amino)-7-(ethoxycarbonyl)-5-propyl-[1,3]dioxolo[4,5-g]quinolin-5-ium (12) was found to be the most potent derivative with IC50 values of 4.45±0.88, 4.74±0.42, 14.54±1.96, and 32.12±3.66 against A-549, HeLa, SGC-7901, and L-02 cells, respectively, stronger than the positive controls 5-FU and MTX. Furthermore, compound 12 had the most potent bacterial inhibitory activity. The MIC of this compound against both E. coli and S. aureus was 3.125 nmol ? mL?1, which was smaller than that against the reference agents amoxicillin and ciprofloxacin.

New Quinoline derivatives: Synthesis and evaluation for antiinflammatory and analgesic properties - Note 1

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Preparation of 1-(lower alkyl)-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acids

A process for producing a compound of the formula: SPC1 Wherein Z is CH or N; R is a lower alkyl group, a lower alkenyl group, a cycloalkyl group or a hydroxyalkyl group; R1 is a hydrogen atom or lower alkyl group; when Z is N, R2, R3 and R4 are a hydrogen atom, a halogen atom a lower alkyl group, a lower alkoxyl group, a lower hydroxyalkyl group, a lower acyloxyalkyl group, trihalogenoalkyl group, a carboxyl group, a cyano group, or an aralkyl group; when Z is CH, R2, R3 and R4 are a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxyl group, a trihalogenoalkyl group, a cyano group, a nitro group, an alkylmercapto group, a lower alkylenedioxy group, or a lower alkylene bridge attached to the quinoline nucleus, which comprises heating a compound of the formula SPC2 Wherein R, R1, R2, R3, R4 and Z are as defined above, followed, if desired, by hydrolyzing the product obtained, is disclosed. The product is useful as an antibacterial agent. An intermediate having the formula: SPC3 Wherein A is OR or a halogen atom, and R, R1, R2, R3, R4 and Z are as defined above, and a process for its preparation are also disclosed.