269054-87-7

Upstream product

• 123-91-1 1,4-dioxane 
• 269055-64-3 5-bromo-4-chloro-N-(2,4,6-trimethylphenyl)-2-pyrimidinamine 
• 60-29-7 diethyl ether 
• 873-74-5 4-Aminobenzonitrile 

Downstream Products

• 269054-88-8 4-[[5-bromo-2-[(2,4,6-trimethylphenyl)amino]-4-pyrimidinyl]amino]benzonitrile 

Relevant academic research and scientific papers

Prodrugs of hiv replication inhibiting pyrimidines

The present invention concerns compounds of formula (A1)(A2)N—R1 (I),the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 is substituted C1-6alkyl; —S(=O)—R8; —S(=O)2—R8; C7-12alkylcarbonyl; optionally substituted C1-6alkyloxycarbonylC1-6alkylcarbonyl; with R8 being C1-6alkyl, aryl1 or Het1; (A1)(A2)N— is the covalently bonded form of the corresponding intermediate of formula (A1)(A2)N—H, which is a HIV replication inhibiting pyrimidine of formula 1