26906-01-4

Basic information

• Product Name: 2-(Allyloxy)benzyl alcohol
• Synonyms: 1-Allyloxy-2-(hydroxymethyl)benzene;2-(Allyloxy)benzyl alcohol;2-Allyloxybenzenemethanol;[2-(allyloxy)phenyl]methanol(SALTDATA: FREE)
• CAS NO: 26906-01-4
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Mol File: 26906-01-4.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 97.5-98.0 °C(Press: 1 Torr)
• Appearance: /
• Density: 1.056±0.06 g/cm3(Predicted)
• PKA: 14.41±0.10(Predicted)
• CAS DataBase Reference: 2-(Allyloxy)benzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Allyloxy)benzyl alcohol(26906-01-4)
• EPA Substance Registry System: 2-(Allyloxy)benzyl alcohol(26906-01-4)

Safety Data

• Hazardous Substances Data: 26906-01-4(Hazardous Substances Data)

Usage

Physical state

Colorless liquid A transparent, colorless liquid without any color.

Odor

Mild, floral A gentle, pleasant scent resembling flowers.

Usage in perfumes and personal care products

Fragrance ingredient Used to provide a pleasant and desirable aroma in various cosmetic and personal care products.

Synthesis of other chemicals and pharmaceuticals

Building block Acts as a starting material or intermediate in the production of other chemical compounds and medications.

Skin irritation

Moderate Can cause some redness, itching, or irritation when in contact with the skin, necessitating careful handling.

Reactivity

Oxidizing agents, acids, and bases Can undergo chemical reactions with these substances, potentially leading to hazardous conditions or products.

Fire hazard

Highly toxic fumes When involved in a fire, it can produce toxic gases that pose a significant health risk.

Applications

Chemical and cosmetic industries Widely used in both industries for various purposes, including fragrances, chemical synthesis, and pharmaceutical development.

Upstream product

• 90-01-7 salicylic alcohol 
• 106-95-6 allyl bromide 
• 90-02-8 salicylaldehyde 
• 28752-82-1 2-(allyloxy)benzaldehyde 
• 122080-54-0 Se-phenyl 2-(allyloxy)selenobenzoate 
• 61493-61-6 ethyl 2-(allyloxy)benzoate 

Downstream Products

• 110731-13-0 allyl o-methoxymethylphenyl ether 
• 28752-82-1 2-(allyloxy)benzaldehyde 
• 341036-48-4 2,3-dihydro-3-hydroxymethyl-4H-benzopyran-4-one 
• 61463-06-7 1-(3-(2-hydroxybenzyl)-2,4,6-trimethoxyphenyl)-3-phenylpropan-1-one 
• 319918-15-5 1-(bromomethyl)-2-(prop-2-en-1-yloxy)benzene 
• 1413932-61-2 1-(allyloxy)-2-({[2-(allyloxy)benzyl]oxy}methyl)benzene 

Relevant articles and documents

Tandem Olefin Isomerization/Cyclization Catalyzed by Complex Nickel Hydride and Br?nsted Acid

We disclose a nickel/Br?nsted acid-catalyzed tandem process consisting of double bond isomerization of allyl ethers and amines and subsequent intramolecular reaction with nucleophiles. The process is accomplished by [(Me3P)4NiH]N(SO2CF3)2 in the presence of triflic acid. The methodology provides rapid access to tetrahydropyran-fused indoles and other oxacyclic scaffolds under very low catalyst loadings.

Tetrahydrobenzochromene Synthesis Enabled by a Deconjugative Alkylation/Tsuji-Saegusa-Ito Oxidation on Knoevenagel Adducts

A modular and practical route to versatile cyano-1,3-dienes by a sequence involving deconjugative alkylation and "Tsuji-Saegusa-Ito oxidation" is reported. In this letter, the versatility of the products is also explored, including a route to benzochromene scaffolds common to many natural products.

Modular Synthesis of Diverse Natural Product-Like Macrocycles: Discovery of Hits with Antimycobacterial Activity

A modular synthetic approach was developed in which variation of the triplets of building blocks used enabled systematic variation of the macrocyclic scaffolds prepared. The approach was demonstrated in the synthesis of 17 diverse natural product-like macrocyclic scaffolds of varied (12–20-membered) ring size. The biological relevance of the chemical space explored was demonstrated through the discovery of a series of macrocycles with significant antimycobacterial activity.