269077-41-0Relevant academic research and scientific papers
Polycyclic Sulfoximines as New Scaffolds for Drug Discovery
Borst, Mark L. G.,Ouairy, Cécile M. J.,Fokkema, Sander C.,Cecchi, Alessandro,Kerckhoffs, Jessica M. C. A.,De Boer, Vincent L.,Van Den Boogaard, Peter J.,Bus, Rutger F.,Ebens, Rijko,Van Der Hulst, Rob,Knol, Joop,Libbers, Rob,Lion, Zhou M.,Settels, Bart W.,De Wever, Ellen,Attia, Khaled A.,Sinnema, Piet-Jan,De Gooijer, Jesse M.,Harkema, Karen,Hazewinkel, Marieke,Snijder, Susan,Pouwer, Kees
supporting information, p. 335 - 343 (2018/05/14)
The design and synthesis of three novel polycyclic scaffolds containing sulfoximines are presented in this work, which exemplify that sulfoximines represent a real opportunity for the discovery of new drug candidates. Additionally, the structures present at least two points of diversification and contain a high level of sp3-character, hence being very interesting 3D scaffolds. The compounds synthesized were added to the compound collection of the European Lead Factory.
Preparation of novel bridged bicyclic thiomorpholines as potentially useful building blocks in medicinal chemistry
Walker, Daniel,Rogier, D.Joseph
, p. 2966 - 2970 (2013/11/06)
Thiomorpholine and thiomorpholine 1,1-dioxide are important building blocks in medicinal chemistry research, and some analogues containing these moieties have entered human clinical trials. Analogues containing bridged bicyclic thiomorpholines have also s
