26919-86-8

Upstream product

• 118284-49-4 N-(2-methyl-1-phenylprop-1-en-1-yl)acetamide 
• 6668-27-5 2-methyl-1-phenyl-propylamine 
• 108-24-7 acetic anhydride 
• 611-70-1 phenyl isopropyl ketone 
• 170811-38-8 (1R,1'R)-N-(2'-hydroxy-1'-phenylethyl)-2-methyl-1-phenylpropylamine 
• 498542-91-9 (1S,2S)-N-acetyl-1,2-bis(trifluoromethanesulfonamido) cyclohexane 
• 6668-27-5 (R)-2-methyl-1-phenylpropylamine 
• 33617-85-5 (rac)-N-(2-Methyl-1-phenylpropyl)acetamid 

Relevant academic research and scientific papers

Practical enantioselective hydrogenation of α-aryl- and α-carboxyamidoethylenes by rhodium(I)-{1,2-bis[(o-tert-butoxyphenyl) (phenyl)phosphino]ethane}

The rhodium(I)-{1,2-bis[(o-tert-butoxyphenyl)(phenyl)phosphino]ethane} [Rh(I)-(t-Bu-SMS-Phos)] catalyst system displayed prime efficiency in the hydrogenation of large series of aamidostyrenes and a-amidoacrylates. Up to >99.9% enantiomeric excesses coupl

Air-stable P-chiral bidentate phosphine ligand with (1-adamantyl) methylphosphino group

Air-stable diphosphine ligand, (R,R)-2,3-bis((1-adamantyl)-methylphosphino) quinoxaline, was prepared by the reaction of enantiomerically pure (S)-(1-adamantyl)methylphosphine-borane with 2,3-dichloroquinoxaline. The ligand exhibited excellent enantiosele

PROCESS FOR PRODUCING OPTICALLY ACTIVE DIMER OF PHOSPHORUS HETEROCYCLE

Primary phosphine represented by formula (1): ????????[Chem. 1] R-PH2?????(1) (wherein R represents a linear, branched, or cyclic alkyl group having 2 to 20 carbon atoms) is reacted with a compound represented by formula (2): ????????[Chem. 2]

PipPhos and MorfPhos: Privileged monodentate phosphoramidite ligands for rhodium-catalyzed asymmetric hydrogenation

(Chemical Equation Presented) A library of 20 monodentate phosphoramidite ligands has been prepared and applied in rhodium-catalyzed asymmetric hydrogenation. This resulted in the identification of two ligands, PipPhos and MorfPhos, that afford excellent

Asymmetric synthesis of N-protected amino acids by the addition of organolithium carboxyl synthons to ROPHy/SOPHy-derived aldoximes and ketoximes.

A new asymmetric synthesis of alpha-amino acids is described in which the key step is the highly diastereoselective addition of organolithium carboxyl synthons (2-furyllithium, phenyllithium, vinyllithium) to (R)- and (S)-O-(1-phenylbutyl) oximes to give hydroxylamines, with vinyllithium being the most satisfactory nucleophilic reagent. Subsequent reductive cleavage of the N-O bond in hydroxylamines, followed by N-protection, and oxidative cleavage of the carboxyl precursor gave a range of N-protected amino acids and esters. The method was exemplified by the synthesis of a range of derivatives of non-proteinogenic amino acids such as 4-bromophenylalanine, tert-leucine, norvaline, cyclohexyl- and aryl-glycines, 2-amino-8-oxodecanoic acid (Aoda) and alpha-methylvaline.

Kinetic resolution of amines: A highly enantioselective and chemoselective acetylating agent with a unique solvent-induced reversal of stereoselectivity

Solvents lend a hand: Changing the polarity of the reaction solvent from 1,3-dimethyltetrahydropyrimidin-2-one (DMPU) to toluene reverses the stereo-selectivity observed in the acetylation of amines with (1S,2S)-1 (see scheme). Optimizing the reaction conditions led to an unprecedented 90% ee (S) in DMPU at -20°C with a 33% conversion.

Optically active 1,1′-Di-tert-butyl-2,2′-diphosphetanyl and its application in rhodium-catalyzed asymmetric hydrogenations

(1S,1′S,2R,2′R)-1, 1′-Di-tert-butyl-2,2′- diphosphetanyl was prepared from fert-butylphosphine via phosphine-boranes as intermediates. The rhodium complex of the ligand was used as a highly efficient catalyst in asymmetric hydrogenations of α-acetyl-amino

Asymmetric hydrogenation of enamides with Rh-BisP* and Rh-MiniPHOs catalysts. Scope, limitations, and mechanism

The asymmetric hydrogenation of aryl- and alkyl-substituted enamides catalyzed by Rh-BisP* complex affords optically active amides with very high ee values. The Rh-MiniPHOS catalyst gives somewhat less satisfactory results. Hydrogenation of the aryl-subst

Diastereoselective addition of chiral aliphatic imines and 2-alkyl-1,3-oxazolidines to organometallic reagents

The reaction of organocerium reagents with chiral aliphatic imines derived from (R)-O-methylphenylglycinol afforded the corresponding amines with high diastereoselectivity. In contrast, the reaction of Grignard reagents with chiral 2-alkyl-1,3-oxazolidines derived from (R)-N-methylphenylglycinol afforded the amines with changeover in diastereoselectivity.

Chromatographic Resolutions of Racemates, XI. Comparison of Optically Active Polyamides and Cellulose Triacetate

On optically active polyacrylic and polymethacrylic amides (1a-e) as well as on microcrystalline cellulose triacetate (2), numerous racemates including drugs are separated at least partially, the amide 4f completely on cellulose triacetate.By repeated chromatography on the polyamide 1a, (+)- and (-)-mandelic acid (4a) and (+)-hexobarbital (9d) also were obtained optically pure.