26928-22-3

Upstream product

• 622-97-9 1-ethenyl-4-methylbenzene 
• 373-91-1 hypofluorous acid trifluoromethyl ester 
• 73839-45-9 (E)-trimethyl[2-(4-methylphenyl)ethenyl]silane 
• 28321-07-5 1-(2,2-difluorovinyl)-4-methylbenzene 
• 1866-39-3 4-methylcinnamic acid 
• 1866-39-3 trans-p-methylcinnamic acid 
• 624-31-7 4-tolyl iodide 
• 1196894-72-0 (E)-1-(1-bromo-2-fluorovinyl)-4-methylbenzene 
• 1196894-65-1 (2,2-difluoro-1-p-tolylvinyl)trimethylsilane 
• 1196894-64-0 1-(2,2-difluoro-1-iodovinyl)-4-methylbenzene 

Relevant academic research and scientific papers

Stereodivergent hydrodefluorination of: Gem -difluoroalkenes: Selective synthesis of (Z)- and (E)-monofluoroalkenes

We have developed a novel approach for the stereodivergent hydrodefluorination of gem-difluoroalkenes using copper(i) catalysts to obtain stereodefined monofluoroalkenes. Both (Z)- and (E)-terminal monofluoroalkenes were obtained by the hydrodefluorination of gem-difluoroalkenes in the presence of copper(i) catalysts and diboron or hydrosilane, respectively, with high stereoselectivity. DFT calculations were conducted to elucidate the stereoselectivity.

Decarboxylation and fluorination method for cinnamic acid and derivative thereof

The invention discloses a decarboxylation and fluorination method for cinnamic acid and a derivative thereof. The method comprises the steps that the cinnamic acid or the derivative thereof reacts with 1-chloromethyl-4-fluorophenyl-1,4-diazabicyclo[2.2.2]octane bis(tetrafluoroboric acid) salt and an alkali compound in one pot, and the fluorination product (mainly a cis-form structure product) of the cinnamic acid or the derivative thereof is obtained. The method fills in the technical blank on the decarboxylation and fluorination method for carboxylic acid connected with SP2 hybridization carbon atoms in the prior art, and is easy to operate, short in process and high in product yield, and the industrial production requirement is met.

Transition metal free decarboxylative fluorination of cinnamic acids with selectfluor

Herein we report a transition metal free decarboxylative fluorination of cinnamic acids with selectfluor. A range of functionalized cinnamic acid derivatives reacted with 2 equiv. of selectfluor and 4 equiv. of base in hydrophobic solvent and water to afford β-fluorostyrene with good yield and Z-stereoselectivity. Kinetic study was conducted.

Stereoselective synthesis of both stereoisomers of β-fluorostyrene derivatives from a common intermediate

The stereoselective synthesis of both cis- and trans-β-fluorostyrene derivatives from a common intermediate, (Z)-1-aryl-2-fluoro-1-(trimethylsilyl) ethenes, is described. The trans isomers are obtained by a stereospecific replacement of the silyl group in

Acceleration of alkenyltrimethylsilane fluorination under mild conditions using ultrasound

Alkenyltrimethylsilanes are selectively fluorodesilated to alkenyl fluoride very readily by reaction with 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2,2,2]octane bis-tetrafluoroborate (Selectfluor) and N-fluorobenzensulfonimids at room temperature under

Reaction of Fluoroxytrifluoromethane with Ring-Substituted Styrenes: A Structure-Reactivity Study

The reaction of fluoroxytrifluoromethane (FTM) with a group of ring-substituted styrenes has been studied.Reaction products have been determined, and relative rates for addition to the double bond have been measured by a competition method.The data give a straight line when plotted as log (k/kH)vs.Hammett ? values with a ρ of -2.48.A similar plot vs. ?+ gave less satisfactory agreement with linearity and a ρ of 2.18.A mechanism is proposed in which a spin-paired free-radical pair is formed that is converted by electron transfer into an ion pair.